Redox-Gated Potential Micellar Carriers Based on Electrostatic Assembly   of Soft Coordination Suprapolymers

doi:10.1021/la300590t

CORC > 北京大学 > 化学与分子工程学院

	Redox-Gated Potential Micellar Carriers Based on Electrostatic Assembly of Soft Coordination Suprapolymers
	Zhao, Li ; Yan, Yun ; Huang, Jianbin
刊名	langmuir
	2012
关键词	COACERVATE CORE MICELLES POLYION COMPLEX MICELLES BLOCK-COPOLYMERS DRUG-DELIVERY CATIONIC SURFACTANT DIBLOCK COPOLYMER DNA COMPACTION POLYMER STABILITY PH
DOI	10.1021/la300590t
英文摘要	We report in this paper the release and uptake of charged payloads in redox responsive electrostatic micellar systems composed of negatively charged soft iron coordination suprapolymers and positively charged block copolymers. This micellar system was reported in our previous work (Yan, Y.; Lan, Y. R.; de Keizer, A.; Drechsler, M.; Van As, H.; Stuart, M. A. C.; Besseling, N. A. M. Redox responsive molecular assemblies based on metallic coordination polymers. Soft Matter, 2010, 6, 3244-3248), where we proposed that the system can be used as a redox-triggered release and uptake system. In this paper, we successfully selected a negatively charged fluorescent dye, eosin B, as a model cargo to track the release and upload process. Upon being compacted in the mixed micelles of coordination polymers and diblock copolymers, the fluorescence of eosin B was effectively quenched. Once reduction was conducted, excess negative charges were introduced to the mixed micelles so that the negatively charged eosin B was expelled out which was accompanied by the recovery of the fluorescence. The free negatively charged eosin B was able to be taken up by the Fe(II) micelles again if oxidation of Fe(II) was carried out since excess positive charges were produced. Beside eosin B, other charged species, such as various charged macromolecules, were tested to be capable of uptake and release by this micellar system. We suppose this system can be potentially used as a redox-gated micellar carrier for uptake and release of charged cargos.; Chemistry, Multidisciplinary; Chemistry, Physical; Materials Science, Multidisciplinary; SCI(E); PubMed; 5; ARTICLE; 13; 5548-5554; 28
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/149905]
专题	化学与分子工程学院
推荐引用方式 GB/T 7714	Zhao, Li,Yan, Yun,Huang, Jianbin. Redox-Gated Potential Micellar Carriers Based on Electrostatic Assembly of Soft Coordination Suprapolymers[J]. langmuir,2012.
APA	Zhao, Li,Yan, Yun,&Huang, Jianbin.(2012).Redox-Gated Potential Micellar Carriers Based on Electrostatic Assembly of Soft Coordination Suprapolymers.langmuir.
MLA	Zhao, Li,et al."Redox-Gated Potential Micellar Carriers Based on Electrostatic Assembly of Soft Coordination Suprapolymers".langmuir (2012).