Selection of DNA-Encoded Small Molecule Libraries Against Unmodified and   Non-Immobilized Protein Targets

doi:10.1002/anie.201404830

CORC > 北京大学 > 化学与分子工程学院

	Selection of DNA-Encoded Small Molecule Libraries Against Unmodified and Non-Immobilized Protein Targets
	Zhao, Peng ; Chen, Zitian ; Li, Yizhou ; Sun, Dawei ; Gao, Yuan ; Huang, Yanyi ; Li, Xiaoyu
刊名	angewandte chemie international edition
	2014
关键词	DNA DNA-encoded library DNA-templated chemistry drug discovery selection IN-VITRO SELECTION CHEMICAL LIBRARIES LINKED DNA TERMINAL PROTECTION PEPTIDE LIBRARY COMBINATORIAL CHEMISTRY BINDING PROTEINS MICROARRAYS DISCOVERY ASSAY
DOI	10.1002/anie.201404830
英文摘要	The selection of DNA-encoded libraries against biological targets has become an important discovery method in chemical biology and drug discovery, but the requirement of modified and immobilized targets remains a significant disadvantage. With a terminal protection strategy and ligand-induced photo-crosslinking, we show that iterated selections of DNA-encoded libraries can be realized with unmodified and non-immobilized protein targets.; Chemistry, Multidisciplinary; SCI(E); EI; PubMed; 4; ARTICLE; yanyi@pku.edu.cn; xiaoyuli@pku.edu.cn; 38; 10056-10059; 53
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/149667]
专题	化学与分子工程学院工学院
推荐引用方式 GB/T 7714	Zhao, Peng,Chen, Zitian,Li, Yizhou,et al. Selection of DNA-Encoded Small Molecule Libraries Against Unmodified and Non-Immobilized Protein Targets[J]. angewandte chemie international edition,2014.
APA	Zhao, Peng.,Chen, Zitian.,Li, Yizhou.,Sun, Dawei.,Gao, Yuan.,...&Li, Xiaoyu.(2014).Selection of DNA-Encoded Small Molecule Libraries Against Unmodified and Non-Immobilized Protein Targets.angewandte chemie international edition.
MLA	Zhao, Peng,et al."Selection of DNA-Encoded Small Molecule Libraries Against Unmodified and Non-Immobilized Protein Targets".angewandte chemie international edition (2014).