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	曼氏和日本血吸虫副肌球蛋白的抗原肽研究; Studies on Antigenic Peptides of Paramyosins of Schistosoma mansoni and Schistosoma japonicum
	杨俊海 ; 许家喜
	2002
关键词	曼氏血吸虫 日本血吸虫 副肌球蛋白 抗原肽 多肽疫苗 Schistosoma mansoni Schistosoma japonicm paramyosin antigenic peptide peptide vaccine
英文摘要	副肌球蛋白是世界卫生组织选取的用来发展血吸虫疫苗的重要候选蛋白之一.在计算机辅助下,应用PCGene程序,根据曼氏和日本血吸虫副肌球蛋白的氨基酸序列,通过对其亲水性、柔韧性、可接近性和二级结构分析预测出8个抗原肽,并用固相法进行了合成.经Dot-ELISA法测定,其中的2个对抗日本血吸虫免疫球蛋白多克隆抗体(抗-Sj-IgG-PcAb)显示出抗原性,可作为抗血吸虫病合成多肽疫苗的候选肽段.; Paramyosin is one of the important candidates selected by WHO (World Health Organization) for development of a vaccine against schistosomiasis. According to their hydrophilicity, flexibility, accessibility and beta-turn in the secondary structures by the determination of their primary structures, eight antigenic peptides of paramyosins, of Schistosoma mansoni and Schistosoma japonicm have been predicted using program PC-Gene with the aid of computer. They were synthesized by solid phase method using t-Boc chemical strategy. Two of them showed good antigenicity by Dot-ELISA method with anti-Schistosoma japonicum-immunoglobulin polyclonal antibody, anti-Sj-IgG PcAb. They would be as candidate peptides of synthetic peptide vaccine against schistosomiasis.; 国家自然科学基金; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000176074200007&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; SCI(E); 中文核心期刊要目总览(PKU); 中国科技核心期刊(ISTIC); 中国科学引文数据库(CSCD); 0; 6; 423-427; 22
语种	中文
出处	SCI ; 万方 ; http://d.g.wanfangdata.com.cn/Periodical_yjhx200206007.aspx
出版者	有机化学
内容类型	其他
源URL	[http://hdl.handle.net/20.500.11897/78354]
专题	化学与分子工程学院
推荐引用方式 GB/T 7714	杨俊海,许家喜. 曼氏和日本血吸虫副肌球蛋白的抗原肽研究, Studies on Antigenic Peptides of Paramyosins of Schistosoma mansoni and Schistosoma japonicum. 2002-01-01.

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