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	硫叶立德[2,3]-σ重排反应迁移基团活性研究; Studies on the Reactivity of Migrating Group in [2,3]-Sigmatropic Rearrangement of Sulfur Ylides
	李玉叶 ; 黄重行 ; 许鹏飞 ; 张艳 ; 王剑波
	2012
关键词	硫叶立德 3]-σ重排 金属卡宾 迁移基团 催化反应 [2 sulfur ylide [2,3]-sigmatropic rearrangement metal carbene migratory group catalytic reaction
英文摘要	设计并完成了过渡金属铑、铜化合物等的催化下,苯基重氮乙酸乙酯与不同硫醚的硫叶立德[2,3]-σ重排反应.通过1H NMR方法测定混合产物的比例,比较烯丙基、炔丙基与联烯基等不同取代硫醚的反应活性,得到这些迁移基团在硫叶立德[2,3]-σ重排反应中的竞争顺序,以及不同类型催化体系对反应的影响.实验结果为进一步理解和应用该反应提供数据支持.; The [2,3]-sigmatropic rearrangement of sulfur ylides is unique and useful reaction in organic synthesis. In this study, the reactivity of sulfides containing three different migrating groups (propargyl, allyl, and allenyl) in [2,3]-sigmatropic rearrangement of sulfur ylides has been compared. The competition reactions of phenylethyldiazoacetate with sulfides through sulfonium ylide [2,3]-sigmatropic rearrangement are designed under Rh(II)- or Cu(I)-catalyzed reaction conditions. Both intra- and intermolecular competitions of sulfides bearing two different migrating groups have been carried out. The ratio of products has been determined by H-1 NMR in order to compare the reactivity of different sulfides bearing allyl, propargyl or allenyl groups. Obvious disparity of the reactivity of these sulfides in [2,3]-sigmatropic rearrangement has been observed. Experimental data indicate that the tendency of preferential [2,3]-sigmatropic rearrangement has the following order: propargyl sulfide>allyl sulfide>allenyl sulfide. Catalysts such as Rh-2(OAc)(4), Rh-7(O2CCF3)(4), and Cu(CH3CN)(4)PF6 ligated with a series of diimine ligands have been investigated for these reactions. Rh(II) complexes are found more efficient than Cu(I) complexes, and Rh-2(O2CCF3)(4) is more efficient than Rh-2(OAc)(4). The efficiency of different catalytic system has been explained based on the proposed reaction mechanism. The reaction catalyzed by Rh(II) complexes is suggested to be different from that catalyzed by Cu(I) complexes. In the case of Cu(I)-catalyzed reaction, Cu(I)-bonded sulfur ylide is considered as the predominant intermediate, while the [2,3]-sigmatropic rearrangement is suggested to proceed through free ylide. Both steric hindrance and electronic properties of ligands influence the ratio and selectivity in Cu(I)-catalyzed reactions. This study provides useful information for further investigation of [2,3]-sigmatropic rearrangement of sulfur ylides.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000310866100004&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; SCI(E); 中文核心期刊要目总览(PKU); 中国科技核心期刊(ISTIC); 中国科学引文数据库(CSCD); 4; 19; 2024-2028; 70
语种	中文
出处	SCI ; 万方 ; 知网
出版者	化学学报
内容类型	其他
源URL	[http://hdl.handle.net/20.500.11897/46449]
专题	化学与分子工程学院
推荐引用方式 GB/T 7714	李玉叶,黄重行,许鹏飞,等. 硫叶立德[2,3]-σ重排反应迁移基团活性研究, Studies on the Reactivity of Migrating Group in [2,3]-Sigmatropic Rearrangement of Sulfur Ylides. 2012-01-01.

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