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	Challenges from Variation across Regions in Cost Effectiveness Analysis in Multi-Regional Clinical Trials
	Chu, Yunbo ; Dai, Luyan ; Qi, Sheng ; Smith, Matthew Lee ; Huang, Hui ; Li, Yang ; Shen, Ye
	2016
关键词	cost-effectiveness analysis multi-regional clinical trials ethnic factors sensitivity analysis clinical evidence RE-LY TRIAL TASK-FORCE REPORT ATRIAL-FIBRILLATION ECONOMIC EVALUATIONS DABIGATRAN WARFARIN TRANSFERABILITY EVENTS DESIGN
英文摘要	Economic evaluation in the form of cost-effectiveness analysis has become a popular means to inform decisions in healthcare. With multi-regional clinical trials in a global development program becoming a new venue for drug efficacy testing in recent decades, questions in methods for cost-effectiveness analysis in the multi-regional clinical trials setting also emerge. This paper addresses some challenges from variation across regions in cost effectiveness analysis in multi-regional clinical trials. Several discussion points are raised for further attention and a multi-regional clinical trial example is presented to illustrate the implications in industrial application. A general message is delivered to call for a depth discussion by all stakeholders to reach an agreement on a good practice in cost-effectiveness analysis in the multi-regional clinical trials. Meanwhile, we recommend an additional consideration of cost-effectiveness analysis results based on the clinical evidence from a certain homogeneous population as sensitivity or scenario analysis upon data availability.; Fundamental Research Funds for the Central Universities from the Ministry of Education of the People's Republic of China; Research Funds of Renmin University of China [15XNI011]; SCI(E); SSCI; ARTICLE; yeshen@uga.edu; 7
语种	英语
出处	SCI
出版者	FRONTIERS IN PHARMACOLOGY
内容类型	其他
源URL	[http://hdl.handle.net/20.500.11897/458679]
专题	数学科学学院
推荐引用方式 GB/T 7714	Chu, Yunbo,Dai, Luyan,Qi, Sheng,et al. Challenges from Variation across Regions in Cost Effectiveness Analysis in Multi-Regional Clinical Trials. 2016-01-01.

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