HMMotif: predicting sequence motifs governing constitutive exon splicing | |
Xing, Jing ; Huang, Lei ; Lu, Jianhua ; Zhou, Xiaobo ; Li, Hongwei ; Bian, Jiawen | |
2014 | |
关键词 | Splicing regulatory elements ESE ESS Hidden Markov Model SR PROTEINS IDENTIFICATION RECOGNITION DEFINITION SILENCERS ENHANCERS ELEMENTS |
英文摘要 | A computationally effective algorithm HMMotif is proposed to detect two kinds of splicing regulatory factor, which are ESEs and ESSs. HMMotif can make full use of the contextual information from the vicinity of 5' and 3' splice sites on the DNA to predict the hidden state of ESEs and ESSs simultaneously. A constitutive exons database is used for the extracting the EST of the concern area from UCSC database. Experiments on this data verified the effectiveness by comparing HMMotif with the traditional threshold based method.; Biotechnology & Applied Microbiology; SCI(E); 0; ARTICLE; hwli@cug.edu.cn; jwbian@cug.edu.cn; 4; 56-59; 9 |
语种 | 英语 |
出处 | SCI |
内容类型 | 其他 |
源URL | [http://hdl.handle.net/20.500.11897/389758] |
专题 | 数学科学学院 |
推荐引用方式 GB/T 7714 | Xing, Jing,Huang, Lei,Lu, Jianhua,et al. HMMotif: predicting sequence motifs governing constitutive exon splicing. 2014-01-01. |
个性服务 |
查看访问统计 |
相关权益政策 |
暂无数据 |
收藏/分享 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论