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	Waiting cycle times and generalized haldane equality in the steady-state cycle kinetics of single enzymes
	Ge, Hao
	2008
关键词	FREE-ENERGY DIFFERENCES NONEQUILIBRIUM MEASUREMENTS FLUCTUATION THEOREM MOLECULE ENZYMOLOGY ENZYMATIC DYNAMICS RANDOM-WALKS SYSTEMS THERMODYNAMICS EQUILIBRIUM EQUATIONS
英文摘要	Enzyme kinetics are cyclic. A more realistic reversible three-step mechanism of the Michaelis-Menten kinetics is investigated in detail, and three kinds of waiting cycle times T, T+, T- are defined. It is shown that the mean waiting cycle times < T >, < T+>, and < T-> are the reciprocal of the steady-state cycle flux J(ss), the forward steady-state cycle flux J(+)(ss) and the backward steady-state cycle flux J(-)(ss), respectively. We also show that the distribution of T+ conditioned on T+) and the one of T- conditioned on T- < T+ (< T-|T- < T+>) are both just the same as < T >. In addition, the forward and backward stepping probabilities p(+) and p(-) are also defined and discussed, especially their relationship with the cycle fluxes and waiting cycle times. Furthermore, we extend the same results to the n-step, cycle, and finally, experimental and theoretically based evidence are also included.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000252122400010&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Chemistry, Physical; SCI(E); EI; PubMed; 8; ARTICLE; 1; 61-70; 112
语种	英语
出处	PubMed ; SCI ; EI
出版者	journal of physical chemistry b
内容类型	其他
源URL	[http://hdl.handle.net/20.500.11897/314909]
专题	数学科学学院
推荐引用方式 GB/T 7714	Ge, Hao. Waiting cycle times and generalized haldane equality in the steady-state cycle kinetics of single enzymes. 2008-01-01.

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