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	High content image sequence analysis for quantifying calcium signals inside cells with mutant presenilin-1 of familial alzheimer disease
	Li, Fuhai ; Zhou, Xiaobo ; Zhu, Jinmin ; Ma, Jinwen ; Wong, Stephen T.C.
	2008
英文摘要	Mutation of presenilin-1 (PS-1) gene is known to be closely related to the familial Alzheimer disease (FAD), whereas oxidative stress and de-regulation of calcium homeostasis are two important phases. To better understand the biological mechanisms between the two important phases, we present a computerized system of automated high content, time-lapse cellular image sequence analysis to quantify calcium signals inside the single cells with PS-1. The proposed system consists of three major components: cell segmentation, image displacement correction, and calcium signal extraction, denoising, and oscillation detection; some new algorithms are implemented. The validation indicates that the proposed system is effective and reliable. Two patterns of calcium signals: stable and temporal (oscillation) are found in this study. The experimental results confirm the hypothesis that h2o2 has regulatory effect on the calcium signal mediated by PS-1. ? 2008 IEEE.; EI; 0
语种	英语
出处	EI
内容类型	其他
源URL	[http://hdl.handle.net/20.500.11897/158178]
专题	数学科学学院
推荐引用方式 GB/T 7714	Li, Fuhai,Zhou, Xiaobo,Zhu, Jinmin,et al. High content image sequence analysis for quantifying calcium signals inside cells with mutant presenilin-1 of familial alzheimer disease. 2008-01-01.

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