This guest editorial introduces the special issue on "Intelligent Computational Techniques for Multimodal Data". The goal of this special issue was to solve a variety of real-life problems which have uncertainty, imprecision, vagueness, resulting in high performance applications or prototypes for real time system. The special issue touched different hot topics related to Computer Vision, Computational Biology, Multimedia data mining, High-dimensional multimedia data, Deep convolution network, Deep semantic preserving hashing, High-dimensional multimedia classification, Deep CNN and extended residual units, particle swarm optimization, Cyberbullying detection on social multimedia, Multimedia detection algorithm of malicious nodes, Multimedia based fast face recognition, Diversifying personalized mobile multimedia application, Multimedia image edge extraction algorithm, Rumour veracity detection.