Bone cell responses to a low elastic modulus titanium alloy surface immobilized with the natural cross-linker genipin

doi:10.1016/j.surfcoat.2018.03.069

CORC > 金属研究所 > 中国科学院金属研究所

	Bone cell responses to a low elastic modulus titanium alloy surface immobilized with the natural cross-linker genipin
	Sun, YS ; Huang, CY ; Chen, CS ; Chang, JH ; Hou, WT ; Li, SJ ; Hao, YL ; Pan, HB ; Huang, HH
刊名	SURFACE & COATINGS TECHNOLOGY
	2018-09-25
卷号	350 页码:918-924
关键词	Low elastic modulus Ti alloy Immobilization Natural crosslinker Genipin Cell response
ISSN号	0257-8972
DOI	10.1016/j.surfcoat.2018.03.069
英文摘要	In this study, we investigated various responses of human bone marrow mesenchymal stem cells (hMSCs) to a low elastic modulus Ti-24Nb-4Zr-8Sn (Ti2448) alloy surface that underwent immobilization using the natural cross-linker genipin. Specifically, hMSC's adhesion, proliferation, mineralization, and differentiation were evaluated. We also analyzed surface characteristics of the Ti2448 alloy, including chemistry, morphology, roughness, and wettability. Our results suggest that genipin immobilized Ti2448 has the potential to benefit orthopedic and dental implant applications. We found that the immobilization of genipin on a sand-blasted/acid-etched Ti2448 alloy surface significantly enhanced the mineralization of the extracellular matrix as well as the expression of certain osteogenic markers (bone sialoprotein and osteocalcin) in hMSCs. Conversely, surface roughness and hydrophilicity cannot be credited with the improved cellular responses observed in this study. The immobilization of genipin to produce a biomolecular surface on low elastic modulus Ti2448 alloy has considerable potential for bone implant applications.
学科主题	Materials Science, Coatings & Films ; Physics, Applied
语种	英语
WOS记录号	WOS:000444660500095
内容类型	期刊论文
源URL	[http://ir.imr.ac.cn/handle/321006/79956]
专题	金属研究所_中国科学院金属研究所
作者单位	1.Natl Yang Ming Univ, Dept Dent, 155,Sec 2,Li Nong St, Taipei 112, Taiwan 2.Natl Yang Ming Univ, Inst Oral Biol, Taipei 112, Taiwan 3.Far Eastern Mem Hosp, Dept Surg, New Taipei 220, Taiwan 4.Cheng Hsin Gen Hosp, Dent Dept, Taipei 112, Taiwan 5.Chinese Acad Sci, Inst Met Res, Shenyang Natl Lab Mat Sci, Shenyang 110016, Liaoning, Peoples R China 6.Chinese Acad Sci, Shenzhen Inst Adv Technol, Ctr Human Tissues & Organs Degenerat, Shenzhen 518055, Peoples R China 7.Asia Univ, Dept Biomed Informat & Med Engn, Taichung 413, Taiwan 8.China Med Univ, Grad Inst Basic Med Sci, Taichung 404, Taiwan 9.China Med Univ Hosp, Dept Med Res, Taichung 407, Taiwan 10.Taipei Vet Gen Hosp, Dept Stomatol, Taipei 112, Taiwan
推荐引用方式 GB/T 7714	Sun, YS,Huang, CY,Chen, CS,et al. Bone cell responses to a low elastic modulus titanium alloy surface immobilized with the natural cross-linker genipin[J]. SURFACE & COATINGS TECHNOLOGY,2018,350:918-924.
APA	Sun, YS.,Huang, CY.,Chen, CS.,Chang, JH.,Hou, WT.,...&Huang, HH.(2018).Bone cell responses to a low elastic modulus titanium alloy surface immobilized with the natural cross-linker genipin.SURFACE & COATINGS TECHNOLOGY,350,918-924.
MLA	Sun, YS,et al."Bone cell responses to a low elastic modulus titanium alloy surface immobilized with the natural cross-linker genipin".SURFACE & COATINGS TECHNOLOGY 350(2018):918-924.