Cerebral Glucose Metabolism Assessment in Rat Models of Alzheimer's Disease: An F-18-FDG-PET Study

doi:10.1177/1533317515617725

	Cerebral Glucose Metabolism Assessment in Rat Models of Alzheimer's Disease: An F-18-FDG-PET Study
	Huang, Y; Chen, JQ; Cui, SY; Ren, J; Lu, YJ; Nie, BB; Lai, XS; Dan BC(单保慈); Nie BB(聂彬彬); Shan, B
刊名	AMERICAN JOURNAL OF ALZHEIMERS DISEASE AND OTHER DEMENTIAS
	2016
卷号	31 期号:4 页码:333-340
关键词	Alzheimer's disease rat model PET metabolism
ISSN号	1533-3175
DOI	10.1177/1533317515617725
文献子类	Article
英文摘要	Objective: This study was designed to detect the brain glucose metabolism in rat models of Alzheimer's disease (AD) by the application of F-18-2-fluoro-deoxy-d-glucose positron emission tomography (F-18-FDG-PET) and to provide new insights for the early detection of AD. Methods: Forty Wistar rats were randomly divided into 2 groups. Fifteen sham-operated rats were used as a control group. The remaining rats as a premodel group were intracerebroventricularly injected with ibotenic acid and were intraperitoneally injected with d-galactose, of which 15 rats were included as the experimental group. The above-mentioned 2 groups were assigned to Y-maze test and underwent F-18-FDG-PET scanning. Positron emission tomography images were processed with SPM 2.0. Results: The learning and memory skills were weakened in AD rats. Besides, the glucose metabolic activity of AD rats decreased in hippolampus, hypothalamus, insular cortex, piriform cortex, striatum, cingulate gyrus, stria terminalis, and parietal lobe and increased in olfactory bulb, cerebellum, midbrain, pontine, and retrosplenial cortex compared with the control group. Dorsal thalamus had shown both enhanced and reduced glucose metabolic activity. Conclusion: Our data indicate that the changed glucose metabolism in cerebral regions in F-18-FDG-PET imaging could be an important predictor for early AD.
电子版国际标准刊号	1938-2731
语种	英语
WOS记录号	WOS:000376305200005
内容类型	期刊论文
源URL	[http://ir.ihep.ac.cn/handle/311005/287072]
专题	中国科学院高能物理研究所
推荐引用方式 GB/T 7714	Huang, Y,Chen, JQ,Cui, SY,et al. Cerebral Glucose Metabolism Assessment in Rat Models of Alzheimer's Disease: An F-18-FDG-PET Study[J]. AMERICAN JOURNAL OF ALZHEIMERS DISEASE AND OTHER DEMENTIAS,2016,31(4):333-340.
APA	Huang, Y.,Chen, JQ.,Cui, SY.,Ren, J.,Lu, YJ.,...&Tang, CZ.(2016).Cerebral Glucose Metabolism Assessment in Rat Models of Alzheimer's Disease: An F-18-FDG-PET Study.AMERICAN JOURNAL OF ALZHEIMERS DISEASE AND OTHER DEMENTIAS,31(4),333-340.
MLA	Huang, Y,et al."Cerebral Glucose Metabolism Assessment in Rat Models of Alzheimer's Disease: An F-18-FDG-PET Study".AMERICAN JOURNAL OF ALZHEIMERS DISEASE AND OTHER DEMENTIAS 31.4(2016):333-340.