The Relationship of Serum Antigen-Specific and Total Immunoglobulin E with Adult Cardiovascular Diseases

doi:10.7150/ijms.25857

	The Relationship of Serum Antigen-Specific and Total Immunoglobulin E with Adult Cardiovascular Diseases
	Wang, J; Xu, ZY; Wang, T; Guo, XX; Li, Y; Hu, Y; Ma, C; Hu Y(胡毅)
刊名	INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
	2018
卷号	15 期号:11 页码:1098-1104
关键词	Immunoglobulin E Antigen-specific IgE Cardiovascular diseases Immune system
ISSN号	1449-1907
DOI	10.7150/ijms.25857
文献子类	Article
英文摘要	Background: The relationship of serum antigen-specific immunoglobulin E (IgE) with cardiovascular diseases (CVDs) remains poorly understood. This study aimed to explore the association of antigen-specific and total IgE with CVDs using data derived from the National Health and Nutrition Examination Survey (NHANES) 2005-2006. Methods and Results: The association of serum total or antigen-specific IgE levels with CVDs was analyzed by survey-weighted logistic regression modeling, adjusted by age, sex, race, education, body mass index, blood pressure, total cholesterol, C-reactive protein, homocysteine, diabetes, smoking, and alcohol consumption. 4953 subjects were included. Coronary heart disease was significantly related to serum total IgE levels. The association of serum total IgE levels with coronary heart disease was further validated by negative, >= 1 and 1-6 positive antigen-specific IgE. Myocardial infarction was positively associated with serum total IgE levels only when all antigen-specific IgE were negative, but inversely associated with serum total IgE when plant-specific IgE test results were positive. More specifically, myocardial infarction was also inversely related to positive oak, birch, or peanut-specific IgE. In addition, serum total IgE are positively associated with angina when at least one specific IgE were positive. Conclusions: Serum antigen-specific IgE, as well as total IgE, is significantly associated with CVDs independently of a long list of established cardiovascular risk factors, which is more informative than total IgE per se.
WOS关键词	MYOCARDIAL-INFARCTION ; RISK-FACTORS ; MAST-CELLS ; IGE ; ATHEROSCLEROSIS ; ATHEROGENESIS ; MORTALITY ; MICE ; MEN
WOS研究方向	General & Internal Medicine
语种	英语
WOS记录号	WOS:000441914600002
内容类型	期刊论文
源URL	[http://ir.ihep.ac.cn/handle/311005/286221]
专题	高能物理研究所_多学科研究中心高能物理研究所_实验物理中心中国科学院高能物理研究所_中国散裂中子源
作者单位	中国科学院高能物理研究所
推荐引用方式 GB/T 7714	Wang, J,Xu, ZY,Wang, T,et al. The Relationship of Serum Antigen-Specific and Total Immunoglobulin E with Adult Cardiovascular Diseases[J]. INTERNATIONAL JOURNAL OF MEDICAL SCIENCES,2018,15(11):1098-1104.
APA	Wang, J.,Xu, ZY.,Wang, T.,Guo, XX.,Li, Y.,...&胡毅.(2018).The Relationship of Serum Antigen-Specific and Total Immunoglobulin E with Adult Cardiovascular Diseases.INTERNATIONAL JOURNAL OF MEDICAL SCIENCES,15(11),1098-1104.
MLA	Wang, J,et al."The Relationship of Serum Antigen-Specific and Total Immunoglobulin E with Adult Cardiovascular Diseases".INTERNATIONAL JOURNAL OF MEDICAL SCIENCES 15.11(2018):1098-1104.