Significant Enhancement of Photothermal and Photoacoustic Efficiencies for Semiconducting Polymer Nanoparticles through Simply Molecular Engineering

doi:10.1002/adfm.201800135

	Significant Enhancement of Photothermal and Photoacoustic Efficiencies for Semiconducting Polymer Nanoparticles through Simply Molecular Engineering
	Ma, H; Wu, XX; Xu, FJ; Peng, AD; Huang, H; Chen J(陈俊); Xie J(谢进); Yang, L; Dong, T; Wen, KK
刊名	ADVANCED FUNCTIONAL MATERIALS
	2018
卷号	28 期号:23 页码:1800135
关键词	molecular engineering photoacoustic imaging photothermal therapy semiconducting polymer nanoparticles tumors
ISSN号	1616-301X
DOI	10.1002/adfm.201800135
文献子类	Article
英文摘要	Semiconducting polymer nanoparticles (SP NPs) are employed as efficient nanoagents for "all-in-one" theranostic nanoplatforms with dual photoacoustic imaging (PAI) and photothermal therapy (PTT) functions based on their photothermal conversion effect. However, the mechanisms of tuning the PTT efficiency are still elusive, though several SP NPs with high photothermal efficiency are reported. Herein, two donor-acceptor (D-A) SP NPs PTIGSVS and PIIGSVS with the same donor unit but different acceptor units are designed and synthesized. Through tuning the acceptor unit, PTIGSVS shows more planar backbone structure, stronger D-A strength, redshifted absorption, enhanced extinction efficient, weakened emission properties, and more efficient nonradiative decay in comparison to the polymeric analogue PIIGSVS. Thus, PTIGSVS NPs present much higher photothermal conversion efficiencies (74%) than PIIGSVS NPs (11%), resulting in significantly enhanced in vitro and in vivo PAI and PTT performance. This contribution demonstrates that PTIGSVS NPs are superior PA/PTT agents for effective cancer theranostic and shed light on understanding the relationship between molecular structures and photothermal effect of CPs.
电子版国际标准刊号	1616-3028
WOS关键词	MULTIFUNCTIONAL THERANOSTIC AGENT ; CANCER-THERAPY ; LIVING MICE ; ORGANIC NANOPARTICLES ; CONJUGATED POLYMERS ; MOS2 NANOSHEETS ; CONTRAST AGENTS ; DRUG-DELIVERY ; CARBON DOTS ; TUMOR
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
语种	英语
WOS记录号	WOS:000434207800009
内容类型	期刊论文
源URL	[http://ir.ihep.ac.cn/handle/311005/285986]
专题	高能物理研究所_多学科研究中心
作者单位	中国科学院高能物理研究所
推荐引用方式 GB/T 7714	Ma, H,Wu, XX,Xu, FJ,et al. Significant Enhancement of Photothermal and Photoacoustic Efficiencies for Semiconducting Polymer Nanoparticles through Simply Molecular Engineering[J]. ADVANCED FUNCTIONAL MATERIALS,2018,28(23):1800135.
APA	Ma, H.,Wu, XX.,Xu, FJ.,Peng, AD.,Huang, H.,...&Fan, WL.(2018).Significant Enhancement of Photothermal and Photoacoustic Efficiencies for Semiconducting Polymer Nanoparticles through Simply Molecular Engineering.ADVANCED FUNCTIONAL MATERIALS,28(23),1800135.
MLA	Ma, H,et al."Significant Enhancement of Photothermal and Photoacoustic Efficiencies for Semiconducting Polymer Nanoparticles through Simply Molecular Engineering".ADVANCED FUNCTIONAL MATERIALS 28.23(2018):1800135.