Stereotaxic F-18-FDG PET and MRI templates with three-dimensional digital atlas for statistical parametric mapping analysis of tree shrew brain

doi:10.1016/j.jneumeth.2017.09.006

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	Stereotaxic F-18-FDG PET and MRI templates with three-dimensional digital atlas for statistical parametric mapping analysis of tree shrew brain
	Huang Q(黄琪); Shan, BC; Xu, L; Zhou, JN; Sun, H; Liu, H; Li, PL; Liang, SX; Wu, S; Duan, SF
刊名	JOURNAL OF NEUROSCIENCE METHODS
	2018
卷号	293 页码:105-116
关键词	Tree shrew Brain Template Digital atlas Positron emission tomography Magnetic resonance imaging
ISSN号	0165-0270
DOI	10.1016/j.jneumeth.2017.09.006
文献子类	Article
英文摘要	Background: Tree shrews are proposed as an alternative animal model to nonhuman primates due to their close affinity to primates. Neuroimaging techniques are widely used to study brain functions and structures of humans and animals. However, tree shrews are rarely applied in neuroimaging field partly due to the lack of available species specific analysis methods. New method: In this study, 10 PET/CT and 10 MRI images of tree shrew brain were used to construct PET and MRI templates; based on histological atlas we reconstructed a three-dimensional digital atlas with 628 structures delineated; then the digital atlas and templates were aligned into a stereotaxic space. Finally, we integrated the digital atlas and templates into a toolbox for tree shrew brain spatial normalization, statistical analysis and results localization. Results: We validated the feasibility of the toolbox by simulated data with lesions in laterodorsal thalamic nucleus (LD). The lesion volumes of simulated PET and MRI images were (12.97 +/- 3.91) mm(3) and (7.04 +/- 0.84) mm(3). Statistical results at p < 0.005 showed the lesion volumes of PET and MRI were 13.18 mm(3) and 8.06 mm(3) in LD. Comparison with existing method(s): To our knowledge, we report the first PET template and digital atlas of tree shrew brain. Compared to the existing MRI templates, our MRI template was aligned into stereotaxic space. And the toolbox is the first software dedicated for tree shrew brain analysis. Conclusions: The templates and digital atlas of tree shrew brain, as well as the toolbox, facilitate the use of tree shrews in neuroimaging field. (C) 2017 Elsevier B.V. All rights reserved.
电子版国际标准刊号	1872-678X
WOS关键词	POSITRON-EMISSION-TOMOGRAPHY ; PRIMARY VISUAL-CORTEX ; SMALL-ANIMAL PET ; RAT-BRAIN ; TUPAIA-BELANGERI ; WHITE-MATTER ; REGISTRATION ; IMAGES ; VALIDATION ; PRIMATES
WOS研究方向	Biochemistry & Molecular Biology ; Neurosciences & Neurology
语种	英语
WOS记录号	WOS:000418211200013
内容类型	期刊论文
源URL	[http://ir.ihep.ac.cn/handle/311005/285506]
专题	高能物理研究所_核技术应用研究中心高能物理研究所_实验物理中心
通讯作者	Dan BC(单保慈)
作者单位	中国科学院高能物理研究所
推荐引用方式 GB/T 7714	Huang Q,Shan, BC,Xu, L,et al. Stereotaxic F-18-FDG PET and MRI templates with three-dimensional digital atlas for statistical parametric mapping analysis of tree shrew brain[J]. JOURNAL OF NEUROSCIENCE METHODS,2018,293:105-116.
APA	黄琪.,Shan, BC.,Xu, L.,Zhou, JN.,Sun, H.,...&聂彬彬.(2018).Stereotaxic F-18-FDG PET and MRI templates with three-dimensional digital atlas for statistical parametric mapping analysis of tree shrew brain.JOURNAL OF NEUROSCIENCE METHODS,293,105-116.
MLA	黄琪,et al."Stereotaxic F-18-FDG PET and MRI templates with three-dimensional digital atlas for statistical parametric mapping analysis of tree shrew brain".JOURNAL OF NEUROSCIENCE METHODS 293(2018):105-116.