Impact of Titanium Dioxide and Fullerenol Nanoparticles on Caco-2 Gut Epithelial Cells

doi:10.1166/jnn.2018.14540

	Impact of Titanium Dioxide and Fullerenol Nanoparticles on Caco-2 Gut Epithelial Cells
	Xiong, FX; Yang SM(杨生梅); Xiong FX(熊凤霞); Chen K(陈奎); Chang YN(常亚男); Bai X(白雪); Yin WY(尹文艳); Gu WH(古伟宏); Wang QY(王前源); Li J(李娟)
刊名	JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
	2018
卷号	18 期号:4 页码:2387-2393
关键词	Caco-2 Gut Epithelial Cells Titanium Dioxide Fullerenol Nanoparticles
ISSN号	1533-4880
DOI	10.1166/jnn.2018.14540
文献子类	Article
英文摘要	The application of nano-products in the food industry increases the risk of people exposed to nanoparticles. Titanium dioxide nanoparticles (T-NPs) are typically and widely used in food field, while fullerenol nanoparticles (F-NPs) have great promise to be used as food additives. Therefore, it is necessary and important to understand the safety of T-NPs and F-NPs in foods. In the present study, Caco-2 gut epithelial cell line was selected as a model to investigate the impact of T-NPs and F-NPs. The viability and proliferation of Caco-2 gut epithelial cells incubated with different concentrations of T-NPs and F-NPs were observed. The results showed that the two kinds of nanoparticles did not induce cell death even lasting for 48 h. The results of apoptosis and DNA damages in the cells indicated that both T-NPs with 50 and 100 mu g/mL caused Caco-2 gut epithelial cell apoptosis, but didn't cause significantly DNA damages. F-NPs with 200 and 500 mu g/mL concentrations also can induce cell apoptosis but no DNA damage.
电子版国际标准刊号	1533-4899
WOS关键词	ROS
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
语种	英语
WOS记录号	WOS:000426050500016
内容类型	期刊论文
源URL	[http://ir.ihep.ac.cn/handle/311005/285681]
专题	高能物理研究所_多学科研究中心
通讯作者	Li J(李娟)
作者单位	中国科学院高能物理研究所
推荐引用方式 GB/T 7714	Xiong, FX,Yang SM,Xiong FX,et al. Impact of Titanium Dioxide and Fullerenol Nanoparticles on Caco-2 Gut Epithelial Cells[J]. JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,2018,18(4):2387-2393.
APA	Xiong, FX.,杨生梅.,熊凤霞.,陈奎.,常亚男.,...&Chen, GG.(2018).Impact of Titanium Dioxide and Fullerenol Nanoparticles on Caco-2 Gut Epithelial Cells.JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,18(4),2387-2393.
MLA	Xiong, FX,et al."Impact of Titanium Dioxide and Fullerenol Nanoparticles on Caco-2 Gut Epithelial Cells".JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY 18.4(2018):2387-2393.