Selective Surface Enhanced Raman Scattering for Quantitative Detection of Lung Cancer Biomarkers in Superparticle@MOF Structure

doi:10.1002/adma.201702275

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	Selective Surface Enhanced Raman Scattering for Quantitative Detection of Lung Cancer Biomarkers in Superparticle@MOF Structure
	Liu, C; Qiao, XZ; Su, BS; Song, Q; Luo, D; Mo, G; Wang, T; Mo G(默广)
刊名	ADVANCED MATERIALS
	2018
卷号	30 期号:5 页码:1702275
关键词	biomarkers self-assembly surface enhanced Raman scattering (SERS) superparticles volatile organic compounds (VOCs)
ISSN号	0935-9648
DOI	10.1002/adma.201702275
文献子类	Article
英文摘要	Surface enhanced Raman scattering (SERS) is a trace detection technique that extends even to single molecule detection. Its potential application to the noninvasive recognition of lung malignancies by detecting volatile organic compounds (VOCs) that serve as biomarkers would be a breakthrough in early cancer diagnostics. This application, however, is currently limited by two main factors: (1) most VOC biomarkers exhibit only weak Raman scattering; and (2) the high mobility of gaseous molecules results in a low adsorptivity on solid substrates. To enhance the adsorption of gaseous molecules, a ZIF-8 layer is coated onto a self-assembly of gold superparticles (GSPs) in order to slow the flow rate of gaseous biomarkers and depress the exponential decay of the electromagnetic field around the GSP surfaces. Gaseous aldehydes that are released as a result of tumor-specific tissue composition and metabolism, thereby acting as indicators of lung cancer, are guided onto SERS-active GSPs substrates through a ZIF-8 channel. Through a Schiff base reaction with 4-aminothiophenol pregrafted onto gold GSPs, gaseous aldehydes are captured with a 10 ppb limit of detection, demonstrating tremendous prospects for in vitro diagnoses of early stage lung cancer.
电子版国际标准刊号	1521-4095
WOS关键词	METAL-ORGANIC FRAMEWORKS ; ZEOLITIC IMIDAZOLATE FRAMEWORKS ; SINGLE-MOLECULE ; COLLOIDAL SUPERPARTICLES ; EXHALED BREATH ; SERS ; NANOPARTICLES ; NANOCRYSTALS ; SPECTROSCOPY ; CATALYSIS
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
语种	英语
WOS记录号	WOS:000423793100028
内容类型	期刊论文
源URL	[http://ir.ihep.ac.cn/handle/311005/285584]
专题	中国科学院高能物理研究所_中国散裂中子源高能物理研究所_多学科研究中心
作者单位	中国科学院高能物理研究所
推荐引用方式 GB/T 7714	Liu, C,Qiao, XZ,Su, BS,et al. Selective Surface Enhanced Raman Scattering for Quantitative Detection of Lung Cancer Biomarkers in Superparticle@MOF Structure[J]. ADVANCED MATERIALS,2018,30(5):1702275.
APA	Liu, C.,Qiao, XZ.,Su, BS.,Song, Q.,Luo, D.,...&默广.(2018).Selective Surface Enhanced Raman Scattering for Quantitative Detection of Lung Cancer Biomarkers in Superparticle@MOF Structure.ADVANCED MATERIALS,30(5),1702275.
MLA	Liu, C,et al."Selective Surface Enhanced Raman Scattering for Quantitative Detection of Lung Cancer Biomarkers in Superparticle@MOF Structure".ADVANCED MATERIALS 30.5(2018):1702275.