Peroxidase-like activity of MoS2 nanoflakes with different modifications and their application for H2O2 and glucose detection

doi:10.1039/c7tb02676e

	Peroxidase-like activity of MoS2 nanoflakes with different modifications and their application for H2O2 and glucose detection
	Gu ZJ(谷战军); Yu J(余杰); Ma DQ(马东清); Mei LQ(梅林强); Gao Q(高琴); Yin WY(尹文艳); Zhang X(张潇); Yan L(晏亮); Zhao YL(赵宇亮); Yu, J
刊名	JOURNAL OF MATERIALS CHEMISTRY B
	2018
卷号	6 期号:3 页码:487-498
ISSN号	2050-750X
DOI	10.1039/c7tb02676e
文献子类	Article
英文摘要	MoS2 nanoflakes (MoS2 NFs) with a diameter of B390 nm were obtained by a facile one-pot hydrothermal method and the NFs exhibited intrinsic peroxidase-like activity. After being modified by commonly used biocompatible surfactants including polyethyleneimine (PEI), polyacrylic acid (PAA), polyvinylpyrrolidone (PVP), and cysteine (Cys), the peroxidase-like catalytic activities of MoS2 NFs were investigated by using 3,30,5,50-tetramethylbenzidine (TMB) and 2,20-azino-bis(3-ethylbenzothiazoline-6sulfonic acid) diammonium salt (ABTS) as chromogenic substrates. Compared to the polymer modified MoS2 NFs, Cys functionalized MoS2 NFs exhibited a high catalytic activity toward H2O2 in the presence of TMB or ABTS. Zeta potential and Michaelis-Menten analyses implied that the electrostatic force induced affinity or repulsion between the MoS2 NFs and substrates, as well as surface modifications of the MoS2 NFs played a key role in the catalytic reactions. Notably, a new peroxidase-like catalytic reaction mechanism was proposed based on the formation of a transient state of Cys-MoS2 NFs containing H2O2 and ABTS, and the catalytic reaction could occur because the Cys on the surface of the MoS2 NFs served as an electron transfer bridge between H2O2 and ABTS. Based on this finding, we also established a platform for colorimetric detection of H2O2 and glucose using Cys-MoS2 NFs as a peroxidase substitution. The limit of detection (LOD) was determined to be 4.103 mmol L-1 for H2O2, and the linear range (LR) was from 0 to 0.3 mmol L-1. The LOD for glucose was 33.51 mmol L-1 and the LR was from 0.05 to 1 mmol L-1, which is suitable for biomedical diagnosis. This work provides a new insight into the catalytic mechanism of peroxidase-like MoS2 NFs, and paves the way for enzyme-like nanomaterials to be used for medical diagnosis.
电子版国际标准刊号	2050-7518
WOS关键词	MOLYBDENUM-DISULFIDE ; GOLD NANOPARTICLES ; CATALYTIC-ACTIVITY ; ELECTROCHEMICAL DETECTION ; COLORIMETRIC DETECTION ; IRIDIUM NANOPARTICLES ; SYNERGISTIC CATALYST ; PHOTOTHERMAL THERAPY ; HYDROGEN-PEROXIDE ; POLYACRYLIC-ACID
WOS研究方向	Materials Science
语种	英语
WOS记录号	WOS:000422871100014
内容类型	期刊论文
源URL	[http://ir.ihep.ac.cn/handle/311005/285545]
专题	高能物理研究所_多学科研究中心高能物理研究所_实验物理中心
作者单位	中国科学院高能物理研究所
推荐引用方式 GB/T 7714	Gu ZJ,Yu J,Ma DQ,et al. Peroxidase-like activity of MoS2 nanoflakes with different modifications and their application for H2O2 and glucose detection[J]. JOURNAL OF MATERIALS CHEMISTRY B,2018,6(3):487-498.
APA	谷战军.,余杰.,马东清.,梅林强.,高琴.,...&Zhao, YL.(2018).Peroxidase-like activity of MoS2 nanoflakes with different modifications and their application for H2O2 and glucose detection.JOURNAL OF MATERIALS CHEMISTRY B,6(3),487-498.
MLA	谷战军,et al."Peroxidase-like activity of MoS2 nanoflakes with different modifications and their application for H2O2 and glucose detection".JOURNAL OF MATERIALS CHEMISTRY B 6.3(2018):487-498.