A Nanobody-Conjugated DNA Nanoplatform for Targeted Platinum-Drug Delivery

doi:10.1002/anie.201909345

CORC > 化学研究所 > 中国科学院化学研究所

	A Nanobody-Conjugated DNA Nanoplatform for Targeted Platinum-Drug Delivery
	Wu, Tiantian; Liu, Jianbing; Liu, Manman; Liu, Shaoli; Zhao, Shuai; Tian, Run; Wei, Dengshuai; Liu, Yangzhong; Zhao, Yao; Xiao, Haihua
刊名	ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
	2019-09-01
ISSN号	1433-7851
DOI	10.1002/anie.201909345
英文摘要	The targeted delivery of chemotherapeutic drugs is a major challenge in the clinical treatment of cancer. Herein, we constructed a multifunctional DNA nanoplatform as a versatile carrier of the highly potent platinum-based DNA intercalator, 56MESS. In our rational design, 56MESS was efficiently loaded into the double-bundle DNA tetrahedron through intercalation with the DNA duplex. With the integration of a nanobody that both targets and blocks epidermal growth factor receptor (EGFR), the DNA nanocarriers exhibit excellent selectivity for cells with elevated EGFR expression (a common biomarker related to tumor formation) and combined tumor therapy without obvious systemic toxicity. This DNA-based platinum-drug delivery system provides a promising strategy for the treatment of tumors.
语种	英语
WOS记录号	WOS:000483626000001
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/82635]
专题	中国科学院化学研究所
作者单位	Chinese Acad Sci, Inst Chem, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Wu, Tiantian,Liu, Jianbing,Liu, Manman,et al. A Nanobody-Conjugated DNA Nanoplatform for Targeted Platinum-Drug Delivery[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2019.
APA	Wu, Tiantian.,Liu, Jianbing.,Liu, Manman.,Liu, Shaoli.,Zhao, Shuai.,...&Ding, Baoquan.(2019).A Nanobody-Conjugated DNA Nanoplatform for Targeted Platinum-Drug Delivery.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION.
MLA	Wu, Tiantian,et al."A Nanobody-Conjugated DNA Nanoplatform for Targeted Platinum-Drug Delivery".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019).