Characteristics and expression patterns of the lipopolysaccharide-induced TNF-alpha factor (LITAF) gene family in the Pacific oyster, Crassostrea gigas

CORC > 南海海洋研究所 > 中国科学院南海海洋研究所 > 中科院海洋生物资源可持续利用重点实验室

	Characteristics and expression patterns of the lipopolysaccharide-induced TNF-alpha factor (LITAF) gene family in the Pacific oyster, Crassostrea gigas
	Yu, ZN; Yu, F; Zhang, Y; carlzyu@scsio.ac.cn
刊名	FISH & SHELLFISH IMMUNOLOGY
	2012
卷号	33 期号:4 页码:899-908
关键词	Crassostrea Gigas Litaf Expression Pattern Immune Response Diversification
ISSN号	1050-4648
英文摘要	Lipopolysaccharide-induced tumor necrosis factor-alpha factor (LITAF) is a novel transcription factor responsible for lipopolysaccharide (LPS)-induced transcription of tumor necrosis factor-alpha. Here, we identified and characterized five new LITAF genes in a mollusk, Crassostrea gigas. The complete cDNA sequences of these newly-cloned CgLITAFs each contain one small ORF encoding putative proteins ranging from 67 to 132 amino acids in length. Each CgLITAF, except LITAF2, includes a conserved domain with two motifs, (H)XCXXC and CXXC; LITAF2 lacks the N-terminal CXXC motif. Phylogenetic analysis shows that the six CgLITAFs members (including a previously reported one) cluster into two different mollusk LITAF branches, implying an ancient origin of two LITAF genes that later diversified. CgLITAF members show distinct gene expression patterns with higher expression in digestive gland, gill, and mantle. Except for LITAF4 and LITAF6. CgLITAF expressions can be induced selectively and to various degrees by different Pathogen-Associated Molecular Patterns (PAMPs). Our results strongly demonstrated that the CgLITAF gene family has diversified in function such that each gene plays a distinct and non-redundant role in host defense of C. gigas. (C) 2012 Elsevier Ltd. All rights reserved.
学科主题	Fisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences
资助项目	LMB
语种	英语
WOS记录号	WOS:000310185800026
公开日期	2013-08-28
内容类型	期刊论文
源URL	[http://ir.scsio.ac.cn/handle/344004/9782]
专题	南海海洋研究所_中科院海洋生物资源可持续利用重点实验室
通讯作者	carlzyu@scsio.ac.cn
推荐引用方式 GB/T 7714	Yu, ZN,Yu, F,Zhang, Y,et al. Characteristics and expression patterns of the lipopolysaccharide-induced TNF-alpha factor (LITAF) gene family in the Pacific oyster, Crassostrea gigas[J]. FISH & SHELLFISH IMMUNOLOGY,2012,33(4):899-908.
APA	Yu, ZN,Yu, F,Zhang, Y,&carlzyu@scsio.ac.cn.(2012).Characteristics and expression patterns of the lipopolysaccharide-induced TNF-alpha factor (LITAF) gene family in the Pacific oyster, Crassostrea gigas.FISH & SHELLFISH IMMUNOLOGY,33(4),899-908.
MLA	Yu, ZN,et al."Characteristics and expression patterns of the lipopolysaccharide-induced TNF-alpha factor (LITAF) gene family in the Pacific oyster, Crassostrea gigas".FISH & SHELLFISH IMMUNOLOGY 33.4(2012):899-908.