Microbial biotransformation of water-insoluble herbimycin A to 11-hydroxy-(11-demethoxy)-herbimycin C by Eupenicillium sp SD017

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	Microbial biotransformation of water-insoluble herbimycin A to 11-hydroxy-(11-demethoxy)-herbimycin C by Eupenicillium sp SD017
	Xie, LW; Wang, GH; Zhang, H; Ouyang, YC; Sun, W; Li, X; xiecsu@126.com
刊名	JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC
	2010
卷号	62 期号:1 页码:76-80
关键词	Herbimycin a Biotransformation Water-insoluble Anti-tumor Drug O-demethylase
ISSN号	1381-1177
英文摘要	Herbimycin A, a typically water-insoluble anti-tumor drug and an analog of geldanamycin, was transformed by fungus Eupenicillium sp. SD017. The water solubility and anti-tumor activity of converted products were evaluated after separation, purification, and structure elucidation. The results showed that herbimycin A can be converted into herbimycin C 1 and 11-hydroxy-(11-demethoxy)-herbimycin C 2 with water solubility increased. The latter is a novel compound, and its IC50 to A549, MCF-7, Ehrlich and HeLa cells is 152.9, 0.46, 10.7 and 109.3 mu g/ml, respectively, which are nearly in the range of those between herbimycin A and herbimycin C. It is suggested that an O-demethylase or/and methyltransferase may play an important role on biotransformation in this case. This study will firstly serve as a fundamental methodology for further structural alteration and functional improvement of the water-insoluble anti-tumor drugs using microbial resources. (C) 2009 Elsevier B.V. All rights reserved.
学科主题	Biochemistry & Molecular Biology ; Chemistry, Physical
URL标识	查看原文
资助项目	LMB
WOS记录号	WOS:000272316800012
公开日期	2011-07-02
内容类型	期刊论文
源URL	[http://ir.scsio.ac.cn/handle/344004/3918]
专题	南海海洋研究所_中科院海洋生物资源可持续利用重点实验室
通讯作者	xiecsu@126.com
推荐引用方式 GB/T 7714	Xie, LW,Wang, GH,Zhang, H,et al. Microbial biotransformation of water-insoluble herbimycin A to 11-hydroxy-(11-demethoxy)-herbimycin C by Eupenicillium sp SD017[J]. JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC,2010,62(1):76-80.
APA	Xie, LW.,Wang, GH.,Zhang, H.,Ouyang, YC.,Sun, W.,...&xiecsu@126.com.(2010).Microbial biotransformation of water-insoluble herbimycin A to 11-hydroxy-(11-demethoxy)-herbimycin C by Eupenicillium sp SD017.JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC,62(1),76-80.
MLA	Xie, LW,et al."Microbial biotransformation of water-insoluble herbimycin A to 11-hydroxy-(11-demethoxy)-herbimycin C by Eupenicillium sp SD017".JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC 62.1(2010):76-80.