Inhibition effect of procyanidins from lotus seedpod on mouse B16 melanoma in vivo and in vitro

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	Inhibition effect of procyanidins from lotus seedpod on mouse B16 melanoma in vivo and in vitro
	Duan, YQ; Zhang, HH; Xu, FF; Xie, BJ; Yang, XW; Wang, Y; Yan, YS; dyq101@ujs.edu.cn
刊名	FOOD CHEMISTRY
	2010
卷号	122 期号:1 页码:84-91
关键词	Lotus Seedpod Procyanidin Melanoma Anti-cancer Activity Apoptosis Immunomodulatory Activity
ISSN号	0308-8146
英文摘要	Significant growth inhibition effects of procyanidins from lotus (Nelumbo nucifera Gaertn.) seedpod (LSPCs) on mouse melanoma B16 were found both in vivo and in vitro. In vivo treatment with LSPCs inhibited tumour growth in C57BL/6 J mice by 55.3% in terms of average tumour weight. LSPCs can significantly (P < 0.05) decrease lipid peroxidation (LPO) levels and increase the activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) in liver tissue. In vitro assay of anti-cancer activities suggested that LSPCs (25-100 mu g/ml) possessed cytotoxicities against mouse melanoma B16 in a dose-dependent mode. Furthermore, LSPCs had significant (P<0.05) stimulatory effects on mouse splenocyte proliferation. The prevention of tumour growth was exerted through diverse mechanisms, including cell-cycle arrest, induction of tumour cell death by apoptosis and increase of Ca2+ ions, together with stimulation of antioxidant enzyme activities and immunomodulatory activities. (C) 2010 Elsevier Ltd. All rights reserved.
学科主题	Chemistry, Applied ; Food Science & Technology ; Nutrition & Dietetics
URL标识	查看原文
资助项目	LMB
WOS记录号	WOS:000277702200013
公开日期	2011-07-02
内容类型	期刊论文
源URL	[http://ir.scsio.ac.cn/handle/344004/3838]
专题	南海海洋研究所_中科院海洋生物资源可持续利用重点实验室
通讯作者	dyq101@ujs.edu.cn
推荐引用方式 GB/T 7714	Duan, YQ,Zhang, HH,Xu, FF,et al. Inhibition effect of procyanidins from lotus seedpod on mouse B16 melanoma in vivo and in vitro[J]. FOOD CHEMISTRY,2010,122(1):84-91.
APA	Duan, YQ.,Zhang, HH.,Xu, FF.,Xie, BJ.,Yang, XW.,...&dyq101@ujs.edu.cn.(2010).Inhibition effect of procyanidins from lotus seedpod on mouse B16 melanoma in vivo and in vitro.FOOD CHEMISTRY,122(1),84-91.
MLA	Duan, YQ,et al."Inhibition effect of procyanidins from lotus seedpod on mouse B16 melanoma in vivo and in vitro".FOOD CHEMISTRY 122.1(2010):84-91.