Bioactive Novel Indole Alkaloids and Steroids from Deep Sea-Derived Fungus Aspergillus fumigatus SCSIO 41012

CORC > 南海海洋研究所 > 中国科学院南海海洋研究所 > 中科院海洋生物资源可持续利用重点实验室

	Bioactive Novel Indole Alkaloids and Steroids from Deep Sea-Derived Fungus Aspergillus fumigatus SCSIO 41012
	Yang, Bin ; Limbadri, Salendra 1; Luo, Xiaowei 1; Lin, Xiuping ; Liao, Shengrong ; Wang, Junfeng ; Zhou, Xuefeng ; Liu, Yonghong
刊名	MOLECULES
	2018
卷号	23 期号:9 页码:2379
关键词	deep sea-derived fungus Aspergillus fumigatus SCSIO 41012 indole alkaloids steroids antibacterial activity antifungal activity
ISSN号	1420-3049
英文摘要	Two new alkaloids, fumigatosides E (1) and F (2), and a new natural product, 3, 7-diketo-cephalosporin P-1 (6) along with five known compounds (3-5, 7, 8) were isolated from deep-sea derived fungal Aspergillus fumigatus SCSIO 41012. Their structures were determined by extensive spectroscopic data analysis, including 1D, 2D nuclear magnetic resonance (NMR) and mass spectrometry (MS), and comparison between the calculated and experimental electronic circular dichroism (ECD) spectra. In addition, all compounds were tested for antibacterial and antifungal inhibitory activities. Compound 1 showed significant antifungal activity against Fusarium oxysporum f. sp. momordicae with MIC at 1.56 mu g/mL. Compound 4 exhibited significant higher activity against S. aureus (16,339 and 29,213) with MIC values of 1.56 and 0.78 mu g/mL, respectively, and compound 2 exhibited significant activity against A. baumanii ATCC 19606 with a MIC value of 6.25 mu g/mL.
内容类型	期刊论文
源URL	[http://ir.scsio.ac.cn/handle/344004/17637]
专题	南海海洋研究所_中科院海洋生物资源可持续利用重点实验室
作者单位	1.Chinese Acad Sci, South China Sea Inst Oceanol, Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med,Res Ctr Marine M, Guangzhou 510301, Guangdong, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Yang, Bin,Limbadri, Salendra,Luo, Xiaowei,et al. Bioactive Novel Indole Alkaloids and Steroids from Deep Sea-Derived Fungus Aspergillus fumigatus SCSIO 41012[J]. MOLECULES,2018,23(9):2379.
APA	Yang, Bin.,Limbadri, Salendra.,Luo, Xiaowei.,Lin, Xiuping.,Liao, Shengrong.,...&Liu, Yonghong.(2018).Bioactive Novel Indole Alkaloids and Steroids from Deep Sea-Derived Fungus Aspergillus fumigatus SCSIO 41012.MOLECULES,23(9),2379.
MLA	Yang, Bin,et al."Bioactive Novel Indole Alkaloids and Steroids from Deep Sea-Derived Fungus Aspergillus fumigatus SCSIO 41012".MOLECULES 23.9(2018):2379.