Peptides from the Soft Coral-associated Fungus Simplicillium sp SCSIO41209

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	Peptides from the Soft Coral-associated Fungus Simplicillium sp SCSIO41209
	Dai, Yu 1; Liu, Yonghong ; Yang, Bin ; Lu, Yongjun 3,4; Zhou, Xuefeng ; Wang, Junfeng ; Salendra, Limbadri 1; Luo, Xiaowei 1; Pang, Xiaoyan 1; Lin, Yun 3,4
刊名	PHYTOCHEMISTRY
	2018
卷号	154 页码:56
关键词	Simplicillium sp SCSIO41209 Soft coral Peptides Sinulariapeptides Antifungal
ISSN号	0031-9422
英文摘要	Five new peptides, Sinulariapeptides A - E together with seven known peptides (6-12) were isolated from the soft coral associated fungus Simplicillium sp. SCSIO 41209. The structures of the new compounds and their absolute configurations were established on the basis of spectroscopic analysis including NMR, MS and ECD. All the Compounds (except sinulariapeptides B - D) were tested for the inhibitory activities of Mycobacterium tuberculosis protein tyrosine phosphatase B (MptpB), and antifungal activities against five plant pathogenic fungi. Simplicilliumtides B and cyclo(L-Val-L-Pro) showed inhibitory activity with the IC50 values of 35.0 and 25.9 mu M, sinulariapeptides A, simplicilliumtides J, verlamelins A and B exhibited potent inhibition against Colletotrichum asianum with the MIC values of range from 4.9 to 9.8 mu g/mL and simplicilliumtides J, verlamelins A and B displayed inhibition against Pyricularia oryza Cav with the MIC values in the range of 19.5-78.1 mu g/ml, respectively.
内容类型	期刊论文
源URL	[http://ir.scsio.ac.cn/handle/344004/17633]
专题	南海海洋研究所_中科院海洋生物资源可持续利用重点实验室
作者单位	1.Chinese Acad Sci, South China Sea Inst Oceanol, CAS Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med,RNAM Ctr Marine, 164 West Xingang Rd, Guangzhou 510301, Guangdong, Peoples R China 2.Sun Yat Sen Univ, Biomed Ctr, Guangzhou 510275, Guangdong, Peoples R China 3.Sun Yat Sen Univ, Sch Life Sci, Guangzhou 510275, Guangdong, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Dai, Yu,Liu, Yonghong,Yang, Bin,et al. Peptides from the Soft Coral-associated Fungus Simplicillium sp SCSIO41209[J]. PHYTOCHEMISTRY,2018,154:56, 62.
APA	Dai, Yu.,Liu, Yonghong.,Yang, Bin.,Lu, Yongjun.,Zhou, Xuefeng.,...&Lin, Yun.(2018).Peptides from the Soft Coral-associated Fungus Simplicillium sp SCSIO41209.PHYTOCHEMISTRY,154,56.
MLA	Dai, Yu,et al."Peptides from the Soft Coral-associated Fungus Simplicillium sp SCSIO41209".PHYTOCHEMISTRY 154(2018):56.