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	Lipidomics Studies on Mitochondrial Damage of Saccharomyces cerevisiae Induced by Heavy Ion Beam Radiation
	Zhang Miao-Miao1,2,3; Guo Xiao-Peng1,2; Liu Rui-Yuan1; Ma Liang1,3; Gao Yue1,2; Lu Dong1,3; Li Wen-Jian1,3
刊名	CHINESE JOURNAL OF ANALYTICAL CHEMISTRY
	2018-11-01
卷号	46期号:11页码:1714-1723
关键词	Lipidomics Heavy ion beam Mitochondria damage Saccharomyces cerevisiae Utra high performance liquid chromatography-electrospray ionization-mass spectrometry
ISSN号	0253-3820
DOI	10.1016/S1872-2040(18)61123-5
通讯作者	Lu Dong(ld@impcas.ac.cn) ; Li Wen-Jian(wjli@impcas.ac.cn)
英文摘要	Ultra high performance liquid chromatography-electrospray ionization-mass spectrometry (UHPLC-ESI-MS) technique combined with multivariate and univariate data analysis methods was used to analyze lipid metabolomics of mitochondria-damaged Saccharomyces cerevisiae (ResD-4) after heavy ion beam radiation. The composition of lipid metabolites in Control and ResD-4 was detected, and a total of 648 kinds of lipid molecules were identified. The results showed that the orthogonal partial least squares discriminant analysis (OPLS-DA) could accurately distinguish the lipid metabolites of ResD-4 and Control. On the basis of variable importance for the projection (VIP), variation multiple (FC) and difference analysis (p), 12 subfamilies, 54 types of significant difference in lipid molecules were finally screened including DG (16:0/18:1), LPC (18:1), LPE (16:0), LPI (18:1), LPS (18:1), PA (16:0/18:1), PC (31:1), PE (16:0/10:0), PI (15:0/18:1), PS (16:0/16:1), SQDG (37:4), TG (15:0/16:0/18:1), etc. Significant differences in the expression level of lipid molecules showed that the expression levels of DG, TG, SQDG, PA, PC, PI, LPC, LPE and LPI were up-regulated, and PE, PS and LPS were down-regulated. The results showed that S. cerevisiae might respond by adjusting the content of lipid components after mitochondrial damage caused by heavy ion beam radiation. The lipid molecules with significant difference expression level might be potential markers for S. cerevisiae mitochondrial damage induced by heavy ion beam radiation.
收录类别	SCI
WOS关键词	DIHYDROXYACETONE PHOSPHATE ; MEMBRANE ; BIOSYNTHESIS ; MATTER ; LIPIDS
WOS研究方向	Chemistry
WOS类目	Chemistry, Analytical
语种	英语
出版者	ELSEVIER SCIENCE INC
WOS记录号	WOS:000451327200003
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2558243
专题	寒区旱区环境与工程研究所
通讯作者	Lu Dong; Li Wen-Jian
作者单位	1.Chinese Acad Sci, Inst Modern Phys, Lanzhou 73000, Gansu, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Gansu Prov Key Lab Microbial Resources Exploit &, Lanzhou 73000, Gansu, Peoples R China
推荐引用方式 GB/T 7714	Zhang Miao-Miao,Guo Xiao-Peng,Liu Rui-Yuan,et al. Lipidomics Studies on Mitochondrial Damage of Saccharomyces cerevisiae Induced by Heavy Ion Beam Radiation[J]. CHINESE JOURNAL OF ANALYTICAL CHEMISTRY,2018,46(11):1714-1723.
APA	Zhang Miao-Miao.,Guo Xiao-Peng.,Liu Rui-Yuan.,Ma Liang.,Gao Yue.,...&Li Wen-Jian.(2018).Lipidomics Studies on Mitochondrial Damage of Saccharomyces cerevisiae Induced by Heavy Ion Beam Radiation.CHINESE JOURNAL OF ANALYTICAL CHEMISTRY,46(11),1714-1723.
MLA	Zhang Miao-Miao,et al."Lipidomics Studies on Mitochondrial Damage of Saccharomyces cerevisiae Induced by Heavy Ion Beam Radiation".CHINESE JOURNAL OF ANALYTICAL CHEMISTRY 46.11(2018):1714-1723.

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