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	Graphene quantum dots functionalized beta-cyclodextrin and cellulose chiral stationary phases with enhanced enantioseparation performance
	Wu, Qi1,2,3; Gao, Jie1,2,3; Chen, Lixiao1,2,3; Dong, Shuqing1,2; Li, Hui1,2; Qiu, Hongdeng1,2; Zhao, Liang1,2
刊名	Journal of chromatography a
	2019-08-30
卷号	1600页码:209-218
关键词	Graphene quantum dots Cyclodextrin Cellulose Molecular modeling Enantioseparation
ISSN号	0021-9673
DOI	10.1016/j.chroma.2019.04.053
通讯作者	Qiu, hongdeng(hdqiu@licp.cas.cn) ; Zhao, liang(zhaol@licp.cas.cn)
英文摘要	Graphene quantum dots (gqd) functionalized beta-cyclodextrin (beta-cd) and cellulose silica composites were first prepared and applied in hplc as chiral stationary phases (csp) to investigate the effect of gqds on chiral separation. through comparing the enantioseparation performance of gqds functionalized beta-cd or cellulose csps and unmodified beta-cd or cellulose csps, we found gqds enhanced the enantioseparation performance of nature beta-cd, beta-cd-3,5-dimethylphenylcarbamate derivative and cellulose-3,5-dimethylphenylcarbamate derivative. molecular modeling was applied to understand and theoretically study the enhancement mechanism of gqds for enantioseparation. according to molecular simulation results, gqds provide extra interactions such as hydrophobic, hydrogen bond and pi-pi interaction when chiral selector interacts with enantiomers, which enhances the chiral recognition ability indirectly. the molecular simulation results showed a good agreement with the experimental results. our work reveals the enhancement performance of gqds for chiral separation, it can be expected that gqds-based chiral composites and chiral gqds have great prospect in chiral separation and other research fields such as asymmetric synthesis, chiral catalysis, chiral recognition and drug delivery. (c) 2019 elsevier b.v. all rights reserved.
收录类别	SCI
WOS关键词	OXIDE-MAGNETIC NANOCOMPOSITES ; CAPILLARY-ELECTROPHORESIS ; BONDED SILICA ; SEPARATION ; HPLC ; FLUORESCENCE ; RESOLUTION ; MECHANISM ; AMYLOSE ; ACID
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry
WOS类目	Biochemical Research Methods ; Chemistry, Analytical
语种	英语
出版者	ELSEVIER SCIENCE BV
WOS记录号	WOS:000472687800024
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2555402
专题	寒区旱区环境与工程研究所
通讯作者	Qiu, Hongdeng; Zhao, Liang
作者单位	1.Chinese Acad Sci, Lanzhou Inst Chem Phys, Key Lab Chem Northwestern Plant Resources, Lanzhou, Gansu, Peoples R China 2.Chinese Acad Sci, Lanzhou Inst Chem Phys, Key Lab Nat Med Gansu Prov, Lanzhou, Gansu, Peoples R China 3.Univ Chinese Acad Sci, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Wu, Qi,Gao, Jie,Chen, Lixiao,et al. Graphene quantum dots functionalized beta-cyclodextrin and cellulose chiral stationary phases with enhanced enantioseparation performance[J]. Journal of chromatography a,2019,1600:209-218.
APA	Wu, Qi.,Gao, Jie.,Chen, Lixiao.,Dong, Shuqing.,Li, Hui.,...&Zhao, Liang.(2019).Graphene quantum dots functionalized beta-cyclodextrin and cellulose chiral stationary phases with enhanced enantioseparation performance.Journal of chromatography a,1600,209-218.
MLA	Wu, Qi,et al."Graphene quantum dots functionalized beta-cyclodextrin and cellulose chiral stationary phases with enhanced enantioseparation performance".Journal of chromatography a 1600(2019):209-218.

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