Cell Membrane Camouflaged Hydrophobic Drug Nanoflake Sandwiched with Photosensitizer for Orchestration of Chemo-Photothermal Combination Therapy

doi:10.1002/smll.201805544

	Cell Membrane Camouflaged Hydrophobic Drug Nanoflake Sandwiched with Photosensitizer for Orchestration of Chemo-Photothermal Combination Therapy
	Zhang, Lijun 1,2; Zhang, Xiao 1,2; Lu, Guihong 1; Li, Feng 1,2; Bao, Weier 2; Song, Cui 1,2; Wei, Wei 1,2; Ma, Guanghui 1,2
刊名	SMALL
	2019-05-01
卷号	15 期号:20 页码:13
关键词	biomimetic combination therapy hydrophobic drugs nanocrystals photosensitizers
ISSN号	1613-6810
DOI	10.1002/smll.201805544
英文摘要	Many candidate anticancer drugs have suffered from their intrinsic hydrophobicity, which poses several obstacles for clinical application. To overcome this challenge and further improve the performance, herein a nanocrystal-based biomimetic formulation with a sandwich structure is developed. As the core, flake shaped nanocrystals (NCs) with high loading of the hydrophobic drug hydroxycamptothecin (HCPT) are synthesized via a mild nanoprecipitation process by exploring the template effect of serum albumin. Meanwhile, the camouflaged cancer cell membrane (CM) composed of plentiful membrane proteins endows the NCs with homotypic targeting capacity at tumor sites. In addition, the photosensitizer indocyanine green sandwiched between NCs and CM not only converts near infrared light to heat for photothermal treatment but also improves the dissolution of HCPT NCs for chemotherapy. These features corporately achieve the orchestration of chemo-photothermal combination therapy and completely inhibit tumor growth with few adverse effects, showing promise as a new modality for the utilization of hydrophobic drugs to treat cancer.
资助项目	National Key R&D Program of China[2017YFA0207900] ; National Natural Science Foundation of China[21622608] ; strategic priority research program of the Chinese Academy of Sciences[XDB29040303]
WOS关键词	ANTICANCER DRUG ; CANCER-CELLS ; NANOPARTICLES ; DELIVERY ; NANOSUSPENSIONS ; CAMPTOTHECIN ; ANTITUMOR ; ELEMENT
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
语种	英语
出版者	WILEY-V C H VERLAG GMBH
WOS记录号	WOS:000471297400002
资助机构	National Key R&D Program of China ; National Natural Science Foundation of China ; strategic priority research program of the Chinese Academy of Sciences
内容类型	期刊论文
源URL	[http://ir.ipe.ac.cn/handle/122111/29958]
专题	中国科学院过程工程研究所
通讯作者	Wei, Wei; Ma, Guanghui
作者单位	1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Lijun,Zhang, Xiao,Lu, Guihong,et al. Cell Membrane Camouflaged Hydrophobic Drug Nanoflake Sandwiched with Photosensitizer for Orchestration of Chemo-Photothermal Combination Therapy[J]. SMALL,2019,15(20):13.
APA	Zhang, Lijun.,Zhang, Xiao.,Lu, Guihong.,Li, Feng.,Bao, Weier.,...&Ma, Guanghui.(2019).Cell Membrane Camouflaged Hydrophobic Drug Nanoflake Sandwiched with Photosensitizer for Orchestration of Chemo-Photothermal Combination Therapy.SMALL,15(20),13.
MLA	Zhang, Lijun,et al."Cell Membrane Camouflaged Hydrophobic Drug Nanoflake Sandwiched with Photosensitizer for Orchestration of Chemo-Photothermal Combination Therapy".SMALL 15.20(2019):13.