Design of DNA-based innovative computing system of digital comparison

doi:10.1016/j.actbio.2018.09.018

CORC > 长春光学精密机械与物理研究所 > 中国科学院长春光学精密机械与物理研究所

	Design of DNA-based innovative computing system of digital comparison
	Guo, Chunlei 1,2; Geng, Hongmei 2; Zhou, Chunyang 2
刊名	ACTA BIOMATERIALIA
	2018-10-15
卷号	80 页码:58-65
关键词	Digital comparator system Graphene oxide DNA Logic gate Computing
ISSN号	1742-7061
DOI	10.1016/j.actbio.2018.09.018
通讯作者	Guo, Chunlei(cyzhou@ciomp.ac.cn)
英文摘要	Despite great potential and extensive interest in developing biomolecule-based computing, the development of even basic molecular logic gates is still in its infancy. Digital comparator (DC) is the basic unit in traditional electronic computers, but it is difficult to construct a system for achieving large-scale integration. Here, we construct, for the first time, a novel logic computing system of DCs that can compare whether two or more numbers are equal. Our approach is by taking advantage of facile preparation and unique properties of graphene oxide and DNA. The DC system reported in this work is developed by the DNA hybridization and effective combination of GO and single-stranded DNA, which is regarded as the reacting platform. On the basis of this platform and reaction principle, we have developed 2-inputs, 3-inputs, and 4-inputs DCs to realize the comparison of two or more binary numbers. We predict that such a state-of-the-art logic system enables its functionality with large-scale input signals, providing a new direction toward. prototypical DNA-based logic operations and promoting the development of advanced logic computing. (C) 2018 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
资助项目	National Key Research and Development Program of China[2017YFB1104700] ; Natural Science Foundation of China (NSFC)[21404015] ; Natural Science Foundation of China (NSFC)[61774155] ; Natural Science Foundation of China (NSFC)[61705227] ; Jilin Science and Technology Department Project[20150204019GX]
WOS关键词	LOGIC-CIRCUITS ; MAMMALIAN-CELLS ; GRAPHENE OXIDE ; ENZYME-FREE ; CONSTRUCTION ; PLATFORM ; GATES ; NANOSTRUCTURE ; OPERATIONS
WOS研究方向	Engineering ; Materials Science
语种	英语
出版者	ELSEVIER SCI LTD
WOS记录号	WOS:000449133400004
资助机构	National Key Research and Development Program of China ; Natural Science Foundation of China (NSFC) ; Jilin Science and Technology Department Project
内容类型	期刊论文
源URL	[http://ir.ciomp.ac.cn/handle/181722/60529]
专题	中国科学院长春光学精密机械与物理研究所
通讯作者	Guo, Chunlei
作者单位	1.Univ Rochester, Inst Opt, Rochester, NY 14627 USA 2.Chinese Acad Sci, Changchun Inst Opt Fine Mech & Phys, Guo China US Photon Lab, Changchun 130033, Jilin, Peoples R China
推荐引用方式 GB/T 7714	Guo, Chunlei,Geng, Hongmei,Zhou, Chunyang. Design of DNA-based innovative computing system of digital comparison[J]. ACTA BIOMATERIALIA,2018,80:58-65.
APA	Guo, Chunlei,Geng, Hongmei,&Zhou, Chunyang.(2018).Design of DNA-based innovative computing system of digital comparison.ACTA BIOMATERIALIA,80,58-65.
MLA	Guo, Chunlei,et al."Design of DNA-based innovative computing system of digital comparison".ACTA BIOMATERIALIA 80(2018):58-65.