Relationship Among Intron Length, Gene Expression, and Nucleotide Diversity in the Pacific Oyster Crassostrea gigas

doi:10.1007/s10126-018-9838-0

CORC > 海洋研究所 > 中国科学院海洋研究所 > 实验海洋生物学重点实验室

	Relationship Among Intron Length, Gene Expression, and Nucleotide Diversity in the Pacific Oyster Crassostrea gigas
	Song, Kai 1,2,3; Li, Li 1,3,4,5; Zhang, Guofan 1,2,3,5
刊名	MARINE BIOTECHNOLOGY
	2018-10-01
卷号	20 期号:5 页码:676-684
关键词	Single nucleotide polymorphism (SNP) Recombination rates Purifying selection
ISSN号	1436-2228
DOI	10.1007/s10126-018-9838-0
通讯作者	Li, Li(lili@qdio.ac.cn) ; Zhang, Guofan(gfzhang@qdio.ac.cn)
英文摘要	Crassostrea gigas is a model mollusk, but its genetic features have not been studied comprehensively. In this study, we used whole-genome resequencing data to identify and characterize nucleotide diversity and population recombination rate in a diverse collection of 21 C. gigas samples. Our analyses revealed that C. gigas harbors both extremely high genetic diversity and recombination rates across the whole genome as compared with those of the other taxa. The noncoding regions, introns, intergenic spacers, and untranslated regions (UTRs) showed a lower level diversity than the synonymous sites. The larger introns tended to have lower diversity. Moreover, we found a negative association of the non-synonymous diversity with gene expression, which suggested that purifying selection played an important role in shaping genetic diversity. The nucleotide diversity at the 100- and 50-kb levels was positively correlated with population recombination rates, which was expected if the diversity was shaped by purifying selection or hitchhiking of advantageous mutants. Our work gives a general picture of the oyster's polymorphism pattern and its association with recombination rates.
WOS研究方向	Biotechnology & Applied Microbiology ; Marine & Freshwater Biology
语种	英语
出版者	SPRINGER
WOS记录号	WOS:000444297400012
内容类型	期刊论文
源URL	[http://ir.qdio.ac.cn/handle/337002/160262]
专题	海洋研究所_实验海洋生物学重点实验室
通讯作者	Li, Li; Zhang, Guofan
作者单位	1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Shandong, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao 266071, Shandong, Peoples R China 3.Natl & Local Joint Engn Lab Ecol Mariculture, Qingdao 266071, Shandong, Peoples R China 4.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Fisheries & Aquaculture, Qingdao 266071, Shandong, Peoples R China 5.Chinese Acad Sci, Inst Oceanol, 7th Nanhai Rd, Qingdao, Peoples R China
推荐引用方式 GB/T 7714	Song, Kai,Li, Li,Zhang, Guofan. Relationship Among Intron Length, Gene Expression, and Nucleotide Diversity in the Pacific Oyster Crassostrea gigas[J]. MARINE BIOTECHNOLOGY,2018,20(5):676-684.
APA	Song, Kai,Li, Li,&Zhang, Guofan.(2018).Relationship Among Intron Length, Gene Expression, and Nucleotide Diversity in the Pacific Oyster Crassostrea gigas.MARINE BIOTECHNOLOGY,20(5),676-684.
MLA	Song, Kai,et al."Relationship Among Intron Length, Gene Expression, and Nucleotide Diversity in the Pacific Oyster Crassostrea gigas".MARINE BIOTECHNOLOGY 20.5(2018):676-684.