Synthesis of C-coordinated O-carboxymethyl chitosan metal complexes and evaluation of their antifungal activity

doi:10.1038/s41598-018-23283-9

CORC > 海洋研究所 > 中国科学院海洋研究所 > 实验海洋生物学重点实验室

	Synthesis of C-coordinated O-carboxymethyl chitosan metal complexes and evaluation of their antifungal activity
	Liu, Weixiang 1,2,3; Qin, Yukun 1,2; Liu, Song 1,2; Xing, Ronge1,2 ; Yu, Huahua1,2 ; Chen, Xiaolin 1,2; Li, Kecheng 1,2; Li, Pengcheng1,2
刊名	SCIENTIFIC REPORTS
	2018-03-19
卷号	8 页码:10
ISSN号	2045-2322
DOI	10.1038/s41598-018-23283-9
通讯作者	Qin, Yukun(ykqin@qdio.ac.cn) ; Li, Pengcheng(pcli@qdio.ac.cn)
英文摘要	Based on a condensation reaction, a chitosan-derivative-bearing amino pyridine group was prepared and subsequently followed by coordination with cupric ions, zinc ions and nickel ions to synthesize chitosan metal complexes. The calculations using the density functional theory (DFT) show that the copper ions and nickel ions underwent dsp(2) hybridization, the zinc ions underwent sp(3) hybridization, and they all formed a coordination bond with the carbon atom in the p-pi conjugate group. The antifungal properties of O-CSPX-M against Phytophthora capsici (P. capsici), Verticillium alboatrum (V. alboatrum), Botrytis cinerea (B. cinerea) and Rhizoctonia solani (R. solani) were also assayed. Apparently, chitosan metal complexes showed enhanced antifungal activity against four fungi at the tested concentrations compared to that of chitosan. It was shown that Cu complexes can inhibit the growth of P. capsici 100%, and Ni complexes can inhibit the growth of B. cinerea 77.1% at a concentration of 0.4 mg/mL and 0.2 mg/mL, respectively. The pot experiment also verified the result. In addition, the phytotoxicity experiment showed that O-CSPX-M had no obvious toxicity on wheat leaves. This kind of complexes may represent as an attractive direction for chemical modifications of metal fungicides.
资助项目	National Natural Science Foundation of China[41306071] ; Scientific and Technological Innovation Project - Qingdao National Laboratory for Marine Science and Technology[2015ASKJ02] ; Public Science and Technology Research Funds Projects of Ocean[201305016-2] ; Public Science and Technology Research Funds Projects of Ocean[201405038-2] ; CAS STS Program[KFJ-SW-STS-143]
WOS研究方向	Science & Technology - Other Topics
语种	英语
出版者	NATURE PUBLISHING GROUP
WOS记录号	WOS:000427688100038
内容类型	期刊论文
源URL	[http://ir.qdio.ac.cn/handle/337002/158400]
专题	海洋研究所_实验海洋生物学重点实验室
通讯作者	Qin, Yukun; Li, Pengcheng
作者单位	1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Drugs & Bioprod, Qingdao, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Liu, Weixiang,Qin, Yukun,Liu, Song,et al. Synthesis of C-coordinated O-carboxymethyl chitosan metal complexes and evaluation of their antifungal activity[J]. SCIENTIFIC REPORTS,2018,8:10.
APA	Liu, Weixiang.,Qin, Yukun.,Liu, Song.,Xing, Ronge.,Yu, Huahua.,...&Li, Pengcheng.(2018).Synthesis of C-coordinated O-carboxymethyl chitosan metal complexes and evaluation of their antifungal activity.SCIENTIFIC REPORTS,8,10.
MLA	Liu, Weixiang,et al."Synthesis of C-coordinated O-carboxymethyl chitosan metal complexes and evaluation of their antifungal activity".SCIENTIFIC REPORTS 8(2018):10.