Magnetic resonance spectroscopy analysis of neurochemical changes in the atrophic hippocampus of APP/PS1 transgenic mice

doi:10.1016/j.bbr.2017.08.005

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	Magnetic resonance spectroscopy analysis of neurochemical changes in the atrophic hippocampus of APP/PS1 transgenic mice
	Chen, LD; Dan BC(单保慈); Nie BB(聂彬彬); Shan, BC; Zhao, S; Tao, J; Lin, RH; Nie, BB; Zhang, XF; Li, L
刊名	BEHAVIOURAL BRAIN RESEARCH
	2017
卷号	335 页码:26-31
关键词	Alzheimer's disease Neurochemical metabolism Hippocampus N-Acetylaspartate Magnetic resonance spectroscopy
ISSN号	0166-4328
DOI	10.1016/j.bbr.2017.08.005
文献子类	Article
英文摘要	Alzheimer's disease (AD) is characterized by neuropathological changes and progressive cognitive decline, which is associated with the volume loss and neurochemical alterations. However, the specific neurochemical alterations in cerebral regions that contribute to cognitive decline still remain unknown. In the present study, we measured cerebral morphological and neurochemical alterations using structural magnetic resonance imaging (MRI) and proton magnetic resonance spectroscopy (H-1-MRS) in an AD model of APP/PS1 transgenic mice. Voxel-based morphometry (VBM) analysis indicated atrophy of the hippocampus, motor cortex, striatum, amygdaloid body, septal area, bed nucleus of the stria terminalis and accumbens nucleus in APP/PS1 transgenic mice. Furthermore, the hippocampus was selected as a region of interest (ROI) to explore neurochemical metabolism. The results showed that the ratios of N-acetylaspartate/creatine (NAA/Cr) and glutamate/creatine (Glu/Cr) were reduced, while myo-inositol/creatine (min/Cr) was increased in APP/PS1 transgenic mice compared to the wild type mice and accompanied by a decline in learning and memory. Taken together, the present study suggests that hippocampal atrophy and neurochemical changes in NAA, Glu and min may play a causative role in the cognitive decline associated with AD.
电子版国际标准刊号	1872-7549
WOS关键词	MILD COGNITIVE IMPAIRMENT ; ALZHEIMERS-DISEASE PATIENTS ; GLUTAMATE LEVELS ; BRAIN ; DEMENTIA ; MYOINOSITOL ; H-1-MRS ; DIAGNOSIS ; MRS
WOS研究方向	Behavioral Sciences ; Neurosciences & Neurology
语种	英语
WOS记录号	WOS:000412034100004
内容类型	期刊论文
源URL	[http://ir.ihep.ac.cn/handle/311005/285282]
专题	高能物理研究所_核技术应用研究中心高能物理研究所_粒子天体物理中心
作者单位	中国科学院高能物理研究所
推荐引用方式 GB/T 7714	Chen, LD,Dan BC,Nie BB,et al. Magnetic resonance spectroscopy analysis of neurochemical changes in the atrophic hippocampus of APP/PS1 transgenic mice[J]. BEHAVIOURAL BRAIN RESEARCH,2017,335:26-31.
APA	Chen, LD.,单保慈.,聂彬彬.,Shan, BC.,Zhao, S.,...&梁胜祥.(2017).Magnetic resonance spectroscopy analysis of neurochemical changes in the atrophic hippocampus of APP/PS1 transgenic mice.BEHAVIOURAL BRAIN RESEARCH,335,26-31.
MLA	Chen, LD,et al."Magnetic resonance spectroscopy analysis of neurochemical changes in the atrophic hippocampus of APP/PS1 transgenic mice".BEHAVIOURAL BRAIN RESEARCH 335(2017):26-31.