Biomimetic construction of protein-conjugated gold clusters for detecting Hg2+

doi:10.1016/j.colsurfa.2017.01.018

	Biomimetic construction of protein-conjugated gold clusters for detecting Hg2+
	Gao, FP; Gao XY(高学云); He, J; Liu, MQ; Gao FP(高福平); Gao J(高靓); Gao, L; Han, R; Gao, XY
刊名	COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
	2017
卷号	518 页码:80-84
关键词	Metal cluster Biomineralization Fluorescence probe Hg2+
ISSN号	0927-7757
DOI	10.1016/j.colsurfa.2017.01.018
文献子类	Article
英文摘要	Mercury ion (Hg2+) pollution has deleterious effects on the environment and human health. Herein, through one-step biomimetic mineralization of metal salt with a natural protein, we develop an optical sensor system for Hg2+ detection with high selectivity and sensitivity. Glucose oxidase (GOD) serves as both a template and reducing agent to achieve the in situ biomineralization of Au (III), producing stable fluorescent GOD-conjugated gold clusters (GOD-AuCs) with a high yield. The probe above with a uniform core size of around 2.5 nm, has an obvious maximum fluorescence emission peak at 686 nm. GOD-AuCs exhibit good selectivity to Hg2+, in comparison to other metal ions including K+, Na+, Ca2+, Mg2+, Zn2+ and Cu2+. The reason might be that the existence of a small amount of Au+ (21%) on the surface of the cluster, permits strong metallophilic interaction between GOD-AuCs and Hg2+. It results in the instantaneous and remarkable fluorescence quench. Moreover, the intensity of fluorescence quench is found to be linearly depended on the concentration of Hg2+, with a detection limit of 7.5 mu M. These favorable findings promise GOD-AuCs have a good potential in monitoring environmental Hg2+. (C) 2017 Elsevier B.V. All rights reserved.
电子版国际标准刊号	1873-4359
WOS关键词	BIOMEDICAL APPLICATIONS ; METAL NANOCLUSTERS ; AU NANOCLUSTERS ; CANCER
WOS研究方向	Chemistry
语种	英语
WOS记录号	WOS:000395842900010
内容类型	期刊论文
源URL	[http://ir.ihep.ac.cn/handle/311005/285178]
专题	高能物理研究所_多学科研究中心高能物理研究所_加速器中心
作者单位	中国科学院高能物理研究所
推荐引用方式 GB/T 7714	Gao, FP,Gao XY,He, J,et al. Biomimetic construction of protein-conjugated gold clusters for detecting Hg2+[J]. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,2017,518:80-84.
APA	Gao, FP.,高学云.,He, J.,Liu, MQ.,高福平.,...&Gao, XY.(2017).Biomimetic construction of protein-conjugated gold clusters for detecting Hg2+.COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,518,80-84.
MLA	Gao, FP,et al."Biomimetic construction of protein-conjugated gold clusters for detecting Hg2+".COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS 518(2017):80-84.