Near infrared light triggered nitric oxide releasing platform based on upconversion nanoparticles for synergistic therapy of cancer stem-like cells

doi:10.1016/j.scib.2017.06.010

	Near infrared light triggered nitric oxide releasing platform based on upconversion nanoparticles for synergistic therapy of cancer stem-like cells
	Zhang X(张潇); Guo Z(郭钊); Liu J(刘景); Chen K(陈奎); Gu ZJ(谷战军); Zhang, X; Guo, Z; Liu, J; Tian, G; Chen, K
刊名	SCIENCE BULLETIN科学通报
	2017
卷号	62 期号:14 页码:985-996
关键词	Upconversion nanoparticles Nitric oxide Cancer stem-like cells Synergistic effect of NO and chemotherapy Drug resistance reversal
ISSN号	2095-9273
DOI	10.1016/j.scib.2017.06.010
文献子类	Article
英文摘要	Near infrared (NIR) light-driven nitric oxide (NO) release nano-platform based on upconversion nanoparticles (UCNPs) and light sensitive NO precursor Roussin's black salt (RBS) was fabricated to generate NO upon 808 nm irradiation. The application of 808 nm laser as the excitation source could achieve better penetration depth and avoid overheating problem. The combination of UCNPs and RBS could realize the on-demand release of NO at desired time and location by simply controlling the output of NIR laser. Cellular uptake results showed that more nanoparticles were internalized in cancer stem-like cells (CSCs) rather than non-CSCs. Therefore, a synergistic cancer therapy strategy to eradicate both CSCs and non-CSCs simultaneously was developed. Traditional chemo-drug could inhibit non-CSCs but has low killing efficiency in CSCs. However, we found that the combination of NO and chemotherapy could efficiently inhibit CSCs in bulk cells, including inhibiting mammosphere formation ability, decreasing CD44(+)/CD24 subpopulation and reducing tumorigenic ability. The mechanism studies confirmed that NO could not only induce apoptosis but also increase drug sensitivity by declining drug efflux in CSCs. This UCNPs-based platform may provide a new combinatorial strategy of NO and chemotherapy to improve cancer treatment. (C) 2017 Science China Press. Published by Elsevier B.V. and Science China Press. All rights reserved.
电子版国际标准刊号	2095-9281
WOS关键词	IN-VITRO PROPAGATION ; DRUG-RESISTANCE ; CO-DELIVERY ; DOXORUBICIN ; NO ; NANOCOMPOSITES ; INHIBITION ; AGENTS ; CD44 ; ACID
WOS研究方向	Science & Technology - Other Topics
语种	英语
CSCD记录号	CSCD:6093366
WOS记录号	WOS:000409086700007
内容类型	期刊论文
源URL	[http://ir.ihep.ac.cn/handle/311005/284986]
专题	高能物理研究所_多学科研究中心
作者单位	中国科学院高能物理研究所
推荐引用方式 GB/T 7714	Zhang X,Guo Z,Liu J,et al. Near infrared light triggered nitric oxide releasing platform based on upconversion nanoparticles for synergistic therapy of cancer stem-like cells[J]. SCIENCE BULLETIN科学通报,2017,62(14):985-996.
APA	张潇.,郭钊.,刘景.,陈奎.,谷战军.,...&Gu, ZJ.(2017).Near infrared light triggered nitric oxide releasing platform based on upconversion nanoparticles for synergistic therapy of cancer stem-like cells.SCIENCE BULLETIN科学通报,62(14),985-996.
MLA	张潇,et al."Near infrared light triggered nitric oxide releasing platform based on upconversion nanoparticles for synergistic therapy of cancer stem-like cells".SCIENCE BULLETIN科学通报 62.14(2017):985-996.