Towards the modulation of oxidative damage, apoptosis and tight junction protein in response to dietary leucine deficiency: A likely cause of ROS-induced gill structural integrity impairment | |
Jiang, Wei-Dan1,2,3; Deng, Yu-Ping1; Zhou, Xiao-Qiu1,2,3; Liu, Yang1,2,3; Jiang, Jun1,2,3; Kuang, Sheng-Yao4; Tang, Ling4; Tang, Wu-Neng4; Wu, Pei1; Zhang, Yong-An | |
刊名 | FISH & SHELLFISH IMMUNOLOGY |
2017-11-01 | |
卷号 | 70期号:1页码:609-620 |
关键词 | Leucine Gill Tight junction Structural integrity Inflammatory |
ISSN号 | 1050-4648 |
DOI | 10.1016/j.fsi.2017.09.049 |
英文摘要 | The current study explored the protective effect of leucine on antioxidant status, apoptosis and tight junction damage in the gill of grass carp (Ctenopharyngodon idella Val.). The trial was conducted by feeding grass carp with six graded level of leucine (7.1, 8.9, 11.0, 133, 15.2 and 17.1 g kg(-1) diet) for 8 weeks. The fish were fed to apparent satiation 4 times per day. The results indicated that compared with the leucine deficiency group, 8.9-11.3 g leucine kg(-1) diet supplementations decreased protein carbonyl (PC), malondialdehyde (MDA) and ROS contents, which may be partially attributed to the improvement of antioxidant status in the gill by increasing hydroxyl radical capacity and anti-superoxide radicals, glutathione contents and the activities and mRNA levels of Cu/Zn superoxide dismutase (SOD1), glutathione peroxidase (GPx), catalase (CAT), glutathione-S-transferase (GST) and glutathione reductase (GR), that referring to the up-regulation of nuclear factor erythroid 2-related factor 2 (Nrf2) mRNA expression. Moreover, leucine deficiency induced DNA fragmentation via the up-regulation of caspase-3, caspase-8 and caspase-9 expressions and down-regulation of target of rapamycin and ribosomal S6 protein kinase 1 expressions. Furthermore, leucine deficiency increased interleukin-1 beta (IL-1 beta), interleukin-8 (IL-8) and tumor necrosis factor-alpha (TNF-alpha) mRNA expression and decreased IL-10 and transforming growth factor beta (TGF-beta), which was partly related to nuclear factor kappa B (NF-kappa B) and its inhibitor (I kappa B). In contrast, the relative mRNA expression of IL-1, IL-8 and TNF-alpha was down-regulated with 8.9-113 g leucine kg(-1) diet supplementations. Finally, the relative mRNA expression of tight junction protein, including occludin, zonula occludens-1, claudin b, claudin 3 and claudin 12 was up-regulated with leucine diet supplementations. Our results indicate that leucine protected the fish gill structural integrity partially because of the inhibition of apoptosis, the improvement of antioxidant status, the regulation of tight junction protein and related signalling molecules mRNA expressions in the fish gill. (C) 2017 Elsevier Ltd. All rights reserved. |
资助项目 | National Basic Research Program of China (973 Program)[2014CB138600] ; National Natural Science Foundation of China[31572632] ; National Natural Science Foundation of China[31672662] ; Outstanding Talents and Innovative Team of Agricultural Scientific Research (Ministry of Agriculture) ; National Department Public Benefit Research Foundation (Agriculture) of China[201003020] ; Science and Technology Support Program of Sichuan Province of China[2014NZ0003] ; Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China[2012NC0007] ; Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China[2013NC0045] ; Foundation of Sichuan Youth Science and Technology Innovation Research Team[2017TD0002] ; Demonstration of Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China[2015CC0011] ; Natural Science Foundation for Young Scientists of Sichuan Province[2014JQ0007] ; Earmarked Fund for China Agriculture Research System[CARS-45] |
WOS关键词 | NF-KAPPA-B ; SALMON SALMO-SALAR ; GROWTH-PERFORMANCE ; ANTIOXIDANT DEFENSE ; CLARIAS-GARIEPINUS ; COPPER EXPOSURE ; AMINO-ACIDS ; GRASS CARP ; FISH ; STRESS |
WOS研究方向 | Fisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences |
语种 | 英语 |
出版者 | ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD |
WOS记录号 | WOS:000416186800064 |
资助机构 | National Basic Research Program of China (973 Program) ; National Basic Research Program of China (973 Program) ; National Basic Research Program of China (973 Program) ; National Basic Research Program of China (973 Program) ; National Basic Research Program of China (973 Program) ; National Basic Research Program of China (973 Program) ; National Basic Research Program of China (973 Program) ; National Basic Research Program of China (973 Program) ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Outstanding Talents and Innovative Team of Agricultural Scientific Research (Ministry of Agriculture) ; Outstanding Talents and Innovative Team of Agricultural Scientific Research (Ministry of Agriculture) ; 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内容类型 | 期刊论文 |
源URL | [http://ir.ihb.ac.cn/handle/342005/30142] |
专题 | 水生生物研究所_其他_期刊论文 |
通讯作者 | Feng, Lin |
作者单位 | 1.Sichuan Agr Univ, Anim Nutr Inst, Chengdu 611130, Sichuan, Peoples R China 2.Sichuan Agr Univ, Fish Nutr & Safety Prod Univ Key Lab Sichuan Prov, Chengdu 611130, Sichuan, Peoples R China 3.Sichuan Agr Univ, Key Lab Anim Dis Resistance Nutr, China Minist Educ, Chengdu 611130, Sichuan, Peoples R China 4.Sichuan Acad Anim Sci, Anim Nutr Inst, Chengdu 611130, Sichuan, Peoples R China 5.Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Hubei, Peoples R China |
推荐引用方式 GB/T 7714 | Jiang, Wei-Dan,Deng, Yu-Ping,Zhou, Xiao-Qiu,et al. Towards the modulation of oxidative damage, apoptosis and tight junction protein in response to dietary leucine deficiency: A likely cause of ROS-induced gill structural integrity impairment[J]. FISH & SHELLFISH IMMUNOLOGY,2017,70(1):609-620. |
APA | Jiang, Wei-Dan.,Deng, Yu-Ping.,Zhou, Xiao-Qiu.,Liu, Yang.,Jiang, Jun.,...&Feng, Lin.(2017).Towards the modulation of oxidative damage, apoptosis and tight junction protein in response to dietary leucine deficiency: A likely cause of ROS-induced gill structural integrity impairment.FISH & SHELLFISH IMMUNOLOGY,70(1),609-620. |
MLA | Jiang, Wei-Dan,et al."Towards the modulation of oxidative damage, apoptosis and tight junction protein in response to dietary leucine deficiency: A likely cause of ROS-induced gill structural integrity impairment".FISH & SHELLFISH IMMUNOLOGY 70.1(2017):609-620. |
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