K+ and Na+-induced self-assembly of telomeric oligonucleotide d(TTAGGG)(n)

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	K+ and Na+-induced self-assembly of telomeric oligonucleotide d(TTAGGG)(n)
	Zhang, XY ; Cao, EH ; Zhang, Y ; Zhou, CQ ; Bai, CL
刊名	JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
	2003-04-01
卷号	20 期号:5 页码:693-701
关键词	Telomeric Dna Nanowire Structure Quadruplex Monovalent Cations Circular Dichroism Atomic Force Microscopy
ISSN号	0739-1102
英文摘要	The telomeric DNA oligomers, d(TTAGGG)(n), where n=1, 2, 4, could self-associate into the multi-stranded structures in appropriate condition and exhibited a different CD spectra. The present of Na+ was more advantage to facilitate the formation of anti-parallel conformation, but the present of K+ enhanced their thermal stability. Spectroscopic analysis of 3, 3'-diethyloxadicarbocyanine (DODC) showed the formation of hairpin quadruplex structures for d(TTAGGG)(2) and d(TTAGGG)(4), but d(TTAGGG) could not. The four-stranded tetraplexes and branched nanowire formed in the present of K+ or Na+ alone were observed by atomic force microscopy (AFM). The ability to self-assemble of d(TTAGGG)(n), into four-stranded tetraplexes and nanowires depends strongly on the number of repeating units and ionic environment. A model to explain how these structures formed is proposed.
语种	英语
出版者	ADENINE PRESS INC
WOS记录号	WOS:000182182000009
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/81089]
专题	中国科学院化学研究所
通讯作者	Cao, EH
作者单位	1.Chinese Acad Sci, Inst Biophys, Ctr Mol Biol, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Inst Chem, Ctr Mol Sci, Beijing 100080, Peoples R China
推荐引用方式 GB/T 7714	Zhang, XY,Cao, EH,Zhang, Y,et al. K+ and Na+-induced self-assembly of telomeric oligonucleotide d(TTAGGG)(n)[J]. JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS,2003,20(5):693-701.
APA	Zhang, XY,Cao, EH,Zhang, Y,Zhou, CQ,&Bai, CL.(2003).K+ and Na+-induced self-assembly of telomeric oligonucleotide d(TTAGGG)(n).JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS,20(5),693-701.
MLA	Zhang, XY,et al."K+ and Na+-induced self-assembly of telomeric oligonucleotide d(TTAGGG)(n)".JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS 20.5(2003):693-701.