Biodegradable electrospun fibers for drug delivery

doi:10.1016/S0168-3659(03)00372-9

CORC > 化学研究所 > 中国科学院化学研究所

	Biodegradable electrospun fibers for drug delivery
	Jing, Z; Xu, XY; Chen, XS; Liang, QZ; Bian, XC; Yang, LX; Jing, XB
刊名	JOURNAL OF CONTROLLED RELEASE
	2003-10-30
卷号	92 期号:3 页码:227-231
关键词	Drug Delivery Electrospinning Ultrafine Fibers
ISSN号	0168-3659
DOI	10.1016/S0168-3659(03)00372-9
英文摘要	The influences of surfactants and medical drugs on the diameter size and uniformity of electrospun poly(L-lactic acid) (PLLA) fibers were examined by adding various surfactants (cationic, anionic, and nonionic) and typical drugs into the PLLA solution. Significant diameter reduction and uniformity improvement were observed. It was shown that the drugs were capsulated inside of the fibers and the drug release in the presence of proteinase K followed nearly zero-order kinetics due to the degradation of the PLLA fibers. Such ultrafine fiber mats containing drugs may find clinical applications in the future. (C) 2003 Elsevier B.V. All rights reserved.
语种	英语
出版者	ELSEVIER SCIENCE BV
WOS记录号	WOS:000186260200001
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/80811]
专题	中国科学院化学研究所
通讯作者	Jing, XB
作者单位	Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China
推荐引用方式 GB/T 7714	Jing, Z,Xu, XY,Chen, XS,et al. Biodegradable electrospun fibers for drug delivery[J]. JOURNAL OF CONTROLLED RELEASE,2003,92(3):227-231.
APA	Jing, Z.,Xu, XY.,Chen, XS.,Liang, QZ.,Bian, XC.,...&Jing, XB.(2003).Biodegradable electrospun fibers for drug delivery.JOURNAL OF CONTROLLED RELEASE,92(3),227-231.
MLA	Jing, Z,et al."Biodegradable electrospun fibers for drug delivery".JOURNAL OF CONTROLLED RELEASE 92.3(2003):227-231.