Novel phototherapeutic agents: Investigation and progress of hypocrellin derivatives

doi:10.1360/03wb0002

CORC > 化学研究所 > 中国科学院化学研究所

	Novel phototherapeutic agents: Investigation and progress of hypocrellin derivatives
	Xu, SJ ; Zhang, XX ; Chen, S ; Zhang, MH ; Shen, T ; Wang, ZP
刊名	CHINESE SCIENCE BULLETIN
	2003-09-01
卷号	48 期号:17 页码:1775-1785
关键词	Photodynamic Therapy Epr Hypocrellins Singlet Oxygen Superoxide Anion Radical
ISSN号	1001-6538
DOI	10.1360/03wb0002
英文摘要	Hypocrellins, as a kind of novel phototherapeutic agents, have several advantages over the clinically used hematoporphyrin derivatives, including high-excited triplet state yield, high phototoxicity, low dark toxicity, and rapid metabolism. However, they exhibit little absorption in the photodynamic window (600-900 nm) and are not water soluble, which limits their application in photodynamic therapy. Sulfonated and metal-ioned hypocrellins have been designed and synthesized to improve their water solubility. Unfortunately, the water-soluble derivatives obtained exhibit lower photodynamic activity than the parent hypocrellins. Thiolated and aminated hypocrellins have also been designed and synthesized to enlarge their photoresponse. Among them, the aminated hypocrellins possess the highest photodynamic activity. We recently have further designed and synthesized some amphiphilic aminated hypocrellin derivatives. Thus, not only the photoresponse but also the water solubility is enhanced. The experiments in vitro and in vivo on the derivatives are under way at present.
语种	英语
出版者	SCIENCE CHINA PRESS
WOS记录号	WOS:000185748300001
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/79687]
专题	中国科学院化学研究所
通讯作者	Shen, T
作者单位	1.Chinese Acad Sci, Inst Chem, Ctr Photochem, Beijing 100080, Peoples R China 2.Harbin Engn Univ, Dept Chem Engn, Harbin 150001, Peoples R China
推荐引用方式 GB/T 7714	Xu, SJ,Zhang, XX,Chen, S,et al. Novel phototherapeutic agents: Investigation and progress of hypocrellin derivatives[J]. CHINESE SCIENCE BULLETIN,2003,48(17):1775-1785.
APA	Xu, SJ,Zhang, XX,Chen, S,Zhang, MH,Shen, T,&Wang, ZP.(2003).Novel phototherapeutic agents: Investigation and progress of hypocrellin derivatives.CHINESE SCIENCE BULLETIN,48(17),1775-1785.
MLA	Xu, SJ,et al."Novel phototherapeutic agents: Investigation and progress of hypocrellin derivatives".CHINESE SCIENCE BULLETIN 48.17(2003):1775-1785.