Electron impact mass spectrometric analysis of a class of 2(1H)-quinoxalin-2-one derivatives

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	Electron impact mass spectrometric analysis of a class of 2(1H)-quinoxalin-2-one derivatives
	Yang, XB ; Ding, ST ; Wang, AB ; Yang, YS
刊名	CHINESE JOURNAL OF ANALYTICAL CHEMISTRY
	2002-02-01
卷号	30 期号:2 页码:148-151
关键词	Quinoxalinone Derivatives Electron Impact Mass Spectrometry Effect Of Different Substituents
ISSN号	0253-3820
英文摘要	A class of 2(1H)-quinoxalin-2-one derivatives: 1-alkyl-3-methyl-2(1H)-quinoxalin-2- one(AMQ,alkyl = H,CH3, Et,n-C3H5, n-C3H11, n-C-16,H-33) were synthesized from o-phenylenediamine. They may be used as highly active fungicides, compounds inhibiting the growth of plants, neuroprotectant for cerebral ischemia, new fluorescent probes, selective antagonists to the non-N-methyl-D-asparate (NMDA) or alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) etc. Their structures have been identified by H-1-nuclear magnetic resonance (NMR) and electron impact mass spectrometry (EI-MS). The effect of different substituents on the EI-MS spectra has been studied. The results show that the mass spectra of all samples contains the characterization of aromatic compounds, such as the series of fragments CnHn+ m/z 78,65,52,39 and/or m/z 77,76,64,63,51,50,38,37. The molecular ion fragments were observed with different abundance in the mass spectra. The samples with substituent which containing carbon atom no more than 2 have the molecular ion peak as base peak. The samples with substituent which containing carbon atom more than 2 also show molecular ion peak, but the base peak is not the molecular ion; as the length of the alkyl chain at the nitrogen on the 1-position increases, the abundance of the molecular ions decreases. Decarbonylation of these compounds may easily generate 1-alkyl-2-methyl-benzimidazole, which resulted from the structure rearrangement upon electron impact. Other fragments appeared in the mass spectra are also discussed. This research work is valuble in many regions, such as the synthesis of quinoxalinone derivatives, as well as the discussion of the pharmacodynamic action and relationship between structural features and biological activity.
语种	英语
出版者	SCIENCE CHINA PRESS
WOS记录号	WOS:000174372200005
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/78425]
专题	中国科学院化学研究所
通讯作者	Yang, XB
作者单位	1.Inst Chem Def, Res Ctr 1, Beijing 100083, Peoples R China 2.Chinese Acad Sci, Inst Chem, Beijing Ctr Mass Spectrometry, Beijing 100080, Peoples R China
推荐引用方式 GB/T 7714	Yang, XB,Ding, ST,Wang, AB,et al. Electron impact mass spectrometric analysis of a class of 2(1H)-quinoxalin-2-one derivatives[J]. CHINESE JOURNAL OF ANALYTICAL CHEMISTRY,2002,30(2):148-151.
APA	Yang, XB,Ding, ST,Wang, AB,&Yang, YS.(2002).Electron impact mass spectrometric analysis of a class of 2(1H)-quinoxalin-2-one derivatives.CHINESE JOURNAL OF ANALYTICAL CHEMISTRY,30(2),148-151.
MLA	Yang, XB,et al."Electron impact mass spectrometric analysis of a class of 2(1H)-quinoxalin-2-one derivatives".CHINESE JOURNAL OF ANALYTICAL CHEMISTRY 30.2(2002):148-151.