Multifunctional vectors system for cancer therapy using single-walled carbon nanotubes and antisense oligonucleotide-modified gold nanoparticles composite materials

doi:10.1504/IJNT.2011.041437

CORC > 化学研究所 > 中国科学院化学研究所

	Multifunctional vectors system for cancer therapy using single-walled carbon nanotubes and antisense oligonucleotide-modified gold nanoparticles composite materials
	Zhu, Yingyue 1; Chen, Wei 1; Qiao, Ruirui 2; Wang, Libing 1; Xu, Chuanlai 1
刊名	INTERNATIONAL JOURNAL OF NANOTECHNOLOGY
	2011
卷号	8 期号:8-9 页码:664-678
关键词	Single-walled Carbon Nanotubes Swnts Antisense Oligodeoxynucleotides Asodns Gold Nanoparticles Gnps Transfection Vector
ISSN号	1475-7435
DOI	10.1504/IJNT.2011.041437
英文摘要	Introduction, A novel transfection vector was designed to deliver the antisense oligodeoxynucleotide into the cancer cells (HL-60). Methods, Antisense oligodeoxynucleotides (ASODNs) were conjugated to the gold nanoparticles (GNPs) through a chemical reaction. The conjugates were then bound to the single-walled carbon nanotubes (SWNTs). This vector system can effectively for induced apoptosis of the cancer cells. Results, The gold nanoparticles helped to improve both transfection and Raman signal. Conclusions, This vector system can be effective for induced apoptosis of the cancer cells, and thus has the potential to be used as a cancer therapy.
语种	英语
出版者	INDERSCIENCE ENTERPRISES LTD
WOS记录号	WOS:000295368600005
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/72671]
专题	中国科学院化学研究所
通讯作者	Xu, Chuanlai
作者单位	1.Jiangnan Univ, Sch Food Sci & Technol, State Key Lab Food Sci & Technol, Wuxi 214122, Jiangsu, Peoples R China 2.Chinese Acad Sci, Inst Chem, Beijing 10008, Peoples R China
推荐引用方式 GB/T 7714	Zhu, Yingyue,Chen, Wei,Qiao, Ruirui,et al. Multifunctional vectors system for cancer therapy using single-walled carbon nanotubes and antisense oligonucleotide-modified gold nanoparticles composite materials[J]. INTERNATIONAL JOURNAL OF NANOTECHNOLOGY,2011,8(8-9):664-678.
APA	Zhu, Yingyue,Chen, Wei,Qiao, Ruirui,Wang, Libing,&Xu, Chuanlai.(2011).Multifunctional vectors system for cancer therapy using single-walled carbon nanotubes and antisense oligonucleotide-modified gold nanoparticles composite materials.INTERNATIONAL JOURNAL OF NANOTECHNOLOGY,8(8-9),664-678.
MLA	Zhu, Yingyue,et al."Multifunctional vectors system for cancer therapy using single-walled carbon nanotubes and antisense oligonucleotide-modified gold nanoparticles composite materials".INTERNATIONAL JOURNAL OF NANOTECHNOLOGY 8.8-9(2011):664-678.