Formation, recognition and bioactivities of a novel G-quadruplex in the STAT3 gene

doi:10.1016/j.bmcl.2011.07.121

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	Formation, recognition and bioactivities of a novel G-quadruplex in the STAT3 gene
	Lin, Sen 2; Li, Sufang 1; Chen, Zan 1; He, Xiangwei 1; Zhang, Youyi 1; Xu, Xiaojie 2; Xu, Ming 1; Yuan, Gu 2
刊名	BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
	2011-10-01
卷号	21 期号:19 页码:5987-5991
关键词	G-quadruplex 3'-flanking Region Cepharanthine Stat3 Gene Gene Regulation
ISSN号	0960-894X
DOI	10.1016/j.bmcl.2011.07.121
英文摘要	G-Quadruplexes have been proved to exist in 5'-untranslated region (5'-UTR), promoter, intron and exon regions of many human genes. Here we report an intramolecular G-quadruplex formed by a G-rich sequence in the 3'-flanking region of signal transducers and activators of transcription 3 (STAT3) gene. The results showed that this G-rich sequence could affect the expression of STAT3. When the STAT3 G-quadruplex was stabilized by a novel non-planar ligand Cepharanthine (CEP), the decreased expression of STAT3 was observed in primary cultured cardiomyocytes. We also demonstrated that the down-regulation of STAT3 was most likely occurred at the transcriptional level. Our results provide a new clue for studying the G-quadruplex formation, recognition and function in the 3'-flanking region of gene. (C) 2011 Elsevier Ltd. All rights reserved.
语种	英语
出版者	PERGAMON-ELSEVIER SCIENCE LTD
WOS记录号	WOS:000294714400071
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/72455]
专题	中国科学院化学研究所
通讯作者	Xu, Ming
作者单位	1.Peking Univ, Inst Vasc Med, Hosp 3, Key Lab Mol Cardiovasc Sci,Minist Educ, Beijing 100191, Peoples R China 2.Peking Univ, Beijing Natl Lab Mol Sci BNLMS, Key Lab Bioorgan Chem & Mol Engn, Minist Educ,Dept Chem Biol,Coll Chem & Mol Engn, Beijing 100871, Peoples R China
推荐引用方式 GB/T 7714	Lin, Sen,Li, Sufang,Chen, Zan,et al. Formation, recognition and bioactivities of a novel G-quadruplex in the STAT3 gene[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2011,21(19):5987-5991.
APA	Lin, Sen.,Li, Sufang.,Chen, Zan.,He, Xiangwei.,Zhang, Youyi.,...&Yuan, Gu.(2011).Formation, recognition and bioactivities of a novel G-quadruplex in the STAT3 gene.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,21(19),5987-5991.
MLA	Lin, Sen,et al."Formation, recognition and bioactivities of a novel G-quadruplex in the STAT3 gene".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 21.19(2011):5987-5991.