Colorimetric and near-infrared fluorescence turn-on molecular probe for direct and highly selective detection of cysteine in human plasma

doi:10.1039/c0jm02497j

CORC > 化学研究所 > 中国科学院化学研究所

	Colorimetric and near-infrared fluorescence turn-on molecular probe for direct and highly selective detection of cysteine in human plasma
	Hao, Wenhui 1; McBride, Arran 1; McBride, Skye 1; Gao, Jian Ping 1; Wang, Zhi Yuan 1,2
刊名	JOURNAL OF MATERIALS CHEMISTRY
	2011
卷号	21 期号:4 页码:1040-1048
ISSN号	0959-9428
DOI	10.1039/c0jm02497j
英文摘要	A highly efficient colorimetric and fluorescence turn-on molecular probe for sensitive and selective detection of biologically important cysteine (Cys) in human plasma is demonstrated using a new zwitterionic dye (M1). The sensing mechanism involves release of the blue-colored and fluorescent M1 from its non-fluorescent, pale-yellow copper complex (M1-Cu) upon exposure to Cys. The new dye has the desired properties suitable for bio-sensing applications, such as distinct blue color, near-infrared (NIR) fluorescence at the wavelength of 875 nm, a large Stokes shift (195 nm), high solubility and stability. This new probe shows both colorimetric and fluorescent responses specifically to Cys over other naturally occurring amino acids, amines and some bioactive thiols and allows for detection of Cys in aqueous solution with a low detection limit of 4.07 x 10(-6) M and in human plasma at the physiologically relevant levels.
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000286110400017
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/71749]
专题	中国科学院化学研究所
通讯作者	Wang, Zhi Yuan
作者单位	1.Carleton Univ, Dept Chem, Ottawa, ON K1S 5B6, Canada 2.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China
推荐引用方式 GB/T 7714	Hao, Wenhui,McBride, Arran,McBride, Skye,et al. Colorimetric and near-infrared fluorescence turn-on molecular probe for direct and highly selective detection of cysteine in human plasma[J]. JOURNAL OF MATERIALS CHEMISTRY,2011,21(4):1040-1048.
APA	Hao, Wenhui,McBride, Arran,McBride, Skye,Gao, Jian Ping,&Wang, Zhi Yuan.(2011).Colorimetric and near-infrared fluorescence turn-on molecular probe for direct and highly selective detection of cysteine in human plasma.JOURNAL OF MATERIALS CHEMISTRY,21(4),1040-1048.
MLA	Hao, Wenhui,et al."Colorimetric and near-infrared fluorescence turn-on molecular probe for direct and highly selective detection of cysteine in human plasma".JOURNAL OF MATERIALS CHEMISTRY 21.4(2011):1040-1048.