Isatin compounds as noncovalent SARS coronavirus 3C-like protease inhibitors

doi:10.1021/jm0602357

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	Isatin compounds as noncovalent SARS coronavirus 3C-like protease inhibitors
	Zhou, Lu ; Liu, Ying ; Zhang, Weilin ; Wei, Ping ; Huang, Changkang ; Pei, Jianfeng ; Yuan, Yaxia ; Lai, Luhua
刊名	JOURNAL OF MEDICINAL CHEMISTRY
	2006-06-15
卷号	49 期号:12 页码:3440-3443
ISSN号	0022-2623
DOI	10.1021/jm0602357
英文摘要	A series of isatin derivatives were synthesized and tested against SARS CoV 3C-like protease. Substitutions at the N-1 and C-5 positions were examined to elucidate the differences in substrate binding sites of the rhinovirus 3C protease and SARS CoV 3C-like protease. Compound 5f shows significant inhibition with an IC50 of 0.37 mu M. Further study showed that, unlike the irreversible covalent binding of isatin derivatives to human rhinovirus 3C protease, the compounds tested in this study are all noncovalent reversible inhibitors.
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000238114700003
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/60221]
专题	中国科学院化学研究所
通讯作者	Liu, Ying
作者单位	1.Peking Univ, State Key Lab Struct Chem Unstable & Stable Speci, Coll Chem & Mol Engn, Beijing 100871, Peoples R China 2.Peking Univ, Ctr Theoret Biol, Beijing 100871, Peoples R China
推荐引用方式 GB/T 7714	Zhou, Lu,Liu, Ying,Zhang, Weilin,et al. Isatin compounds as noncovalent SARS coronavirus 3C-like protease inhibitors[J]. JOURNAL OF MEDICINAL CHEMISTRY,2006,49(12):3440-3443.
APA	Zhou, Lu.,Liu, Ying.,Zhang, Weilin.,Wei, Ping.,Huang, Changkang.,...&Lai, Luhua.(2006).Isatin compounds as noncovalent SARS coronavirus 3C-like protease inhibitors.JOURNAL OF MEDICINAL CHEMISTRY,49(12),3440-3443.
MLA	Zhou, Lu,et al."Isatin compounds as noncovalent SARS coronavirus 3C-like protease inhibitors".JOURNAL OF MEDICINAL CHEMISTRY 49.12(2006):3440-3443.