Ultrafine medicated fibers electrospun from W/O emulsions

doi:10.1016/j.jconrel.2005.07.021

CORC > 化学研究所 > 中国科学院化学研究所

	Ultrafine medicated fibers electrospun from W/O emulsions
	Xu, XL ; Yang, LX ; Xu, XY ; Wang, X ; Chen, XS ; Liang, QZ ; Zeng, J ; Jing, XB
刊名	JOURNAL OF CONTROLLED RELEASE
	2005-11-02
卷号	108 期号:1 页码:33-42
关键词	Emulsion Electrospinning Drug Delivery Polylactide
ISSN号	0168-3659
DOI	10.1016/j.jconrel.2005.07.021
英文摘要	Ultrafine fibers containing water-soluble drugs were successfully electrospun from water-in-oil (W/O) emulsions, in which the aqueous phase contained the water-soluble drugs and the oily phase was a chloroform solution of amphiphilic poly (ethylene glyCol)-poly (L-lactic acid) (PEG-PLLA) diblock copolymer. The diameter of the electrospun fibers was in the range of 300 nm- 1 mu m. A water-soluble anticancer agent, doxorubicin hydrochloride (Dox), was used as the model drug. Its content in the fibers was 1-5 wt.% and it was entirely encapsulated inside the electrospun fibers. Its release from the fibers was controlled by the combined diffusion mechanism and enzymatic degradation mechanism. At the early stage, the diffusion mechanism was predominant and a certain time later, the enzymatic degradation mechanism became predominant. The antitumor activity of the Dox incorporated in the PEG-PLLA fibers against mice glioma cells (C-6 cell lines) was evaluated by MTT method. The results showed that the Dox could be released from the fibers without losing cytotoxicity. (c) 2005 Elsevier B.V All rights reserved.
语种	英语
出版者	ELSEVIER SCIENCE BV
WOS记录号	WOS:000233321200004
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/57805]
专题	中国科学院化学研究所
通讯作者	Jing, XB
作者单位	1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China 3.Shenyang Normal Univ, Dept Chem & Life Sci, Shenyang 110034, Peoples R China
推荐引用方式 GB/T 7714	Xu, XL,Yang, LX,Xu, XY,et al. Ultrafine medicated fibers electrospun from W/O emulsions[J]. JOURNAL OF CONTROLLED RELEASE,2005,108(1):33-42.
APA	Xu, XL.,Yang, LX.,Xu, XY.,Wang, X.,Chen, XS.,...&Jing, XB.(2005).Ultrafine medicated fibers electrospun from W/O emulsions.JOURNAL OF CONTROLLED RELEASE,108(1),33-42.
MLA	Xu, XL,et al."Ultrafine medicated fibers electrospun from W/O emulsions".JOURNAL OF CONTROLLED RELEASE 108.1(2005):33-42.