An implantable immunosuppressive cyclosporine drug delivery system

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	An implantable immunosuppressive cyclosporine drug delivery system
	Wang, SG ; Cai, Q ; Bei, JZ ; Shi, WY ; Xie, LX ; Zhang, X ; Tanaka, J ; Yu, Y ; Tabata, Y
刊名	ASBM6: ADVANCED BIOMATERIALS VI
	2005
卷号	288-289 页码:125-128
关键词	(Glycolide-co-lactide-co-caprolactone) Copolymer Biodegradation Drug Delivery System Corneal Transplantation Cyclosporine Immunosuppressant
ISSN号	1013-9826
英文摘要	In the article a kind biodegradable drug carrier (glycolide-co-lactide-co-caprolactone) tricomponent copolymer (PGLC) was synthesized by ring opening copolymerization of glycolide (GA), lactide (LA) and epsilon-caprolactone (CL), and was used to manufacture an implantable drug preparation---Cyclosporine-PGLC drug delivery system (Cs-PGLC DDS).The Cs could slowly release from the Cs-PGLC DDS near linearly and last for a long time in vitro. A clinically significant Cs concentration in the cornea and anterior chamber could be achieved by implanting the Cs-PGLC DDS in anterior chamber. It was demonstrated that the Cs-PGLC DDS is a long-effective intraocular immunosuppressive agent for remaining corneal allograft clear and significantly prolong its survival time.
语种	英语
出版者	TRANS TECH PUBLICATIONS LTD
WOS记录号	WOS:000230426600031
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/57159]
专题	中国科学院化学研究所
通讯作者	Wang, SG
作者单位	1.Chinese Acad Sci, Inst Chem, Ctr Mol Sci, Beijing 100080, Peoples R China 2.Sandong Eye Inst, Qingdao 266071, Peoples R China
推荐引用方式 GB/T 7714	Wang, SG,Cai, Q,Bei, JZ,et al. An implantable immunosuppressive cyclosporine drug delivery system[J]. ASBM6: ADVANCED BIOMATERIALS VI,2005,288-289:125-128.
APA	Wang, SG.,Cai, Q.,Bei, JZ.,Shi, WY.,Xie, LX.,...&Tabata, Y.(2005).An implantable immunosuppressive cyclosporine drug delivery system.ASBM6: ADVANCED BIOMATERIALS VI,288-289,125-128.
MLA	Wang, SG,et al."An implantable immunosuppressive cyclosporine drug delivery system".ASBM6: ADVANCED BIOMATERIALS VI 288-289(2005):125-128.