Inhibition of HIV-1 TAR RNA-Tat peptide complexation using poly(acrylic acid)

doi:10.1016/j.bbrc.2004.05.148

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	Inhibition of HIV-1 TAR RNA-Tat peptide complexation using poly(acrylic acid)
	Zhao, H; Li, JR; Jiang, L
刊名	BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
	2004-07-16
卷号	320 期号:1 页码:95-99
关键词	Inhibition Poly(Acrylic Acid) Tat Peptide Tar Rna Quartz Crystal Microbalance
ISSN号	0006-291X
DOI	10.1016/j.bbrc.2004.05.148
英文摘要	HIV-1 is regulated at the transcriptional level by the interaction of Tat protein with the transactivation responsive region (TAR) RNA, a 59-base stem-loop structure located at the 5'-end of all nascent HIV-1 transcripts. Here, by targeting the Tat peptide, we found that negatively charged poly(acrylic acid) (PAA) had high affinity with Tat peptide and could inhibit the interaction of TAR with Tat. Therefore, PAA could block HIV replication by binding to Tat not to TAR RNA, providing a new thinking for the design of novel anti-HIV drugs. (C) 2004 Elsevier Inc. All rights reserved.
语种	英语
出版者	ACADEMIC PRESS INC ELSEVIER SCIENCE
WOS记录号	WOS:000222494500015
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/55093]
专题	中国科学院化学研究所
通讯作者	Jiang, L
作者单位	Chinese Acad Sci, Ctr Mol Sci, Inst Chem, Beijing 100080, Peoples R China
推荐引用方式 GB/T 7714	Zhao, H,Li, JR,Jiang, L. Inhibition of HIV-1 TAR RNA-Tat peptide complexation using poly(acrylic acid)[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2004,320(1):95-99.
APA	Zhao, H,Li, JR,&Jiang, L.(2004).Inhibition of HIV-1 TAR RNA-Tat peptide complexation using poly(acrylic acid).BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,320(1),95-99.
MLA	Zhao, H,et al."Inhibition of HIV-1 TAR RNA-Tat peptide complexation using poly(acrylic acid)".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 320.1(2004):95-99.