Osteocompatibility evaluation of poly(glycine ethyl ester-co-alanine ethyl ester)phosphazene with honeycomb-patterned surface topography

doi:10.1002/jbm.a.34282

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	Osteocompatibility evaluation of poly(glycine ethyl ester-co-alanine ethyl ester)phosphazene with honeycomb-patterned surface topography
	Duan, Shun 1; Yang, Xiaoping 1; Mao, Jifu 1; Qi, Bing 1; Cai, Qing 1; Shen, Hong 2; Yang, Fei 2; Deng, Xuliang 3; Wang, Shenguo 2
刊名	JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
	2013-02-01
卷号	101 期号:2 页码:307-317
关键词	Poly(Glycine Ethyl Ester-co-alanine Ethyl Ester)Phosphazene Honeycomb-patterned Biomineralization Osteocompatibility
ISSN号	1549-3296
DOI	10.1002/jbm.a.34282
英文摘要	Biodegradable amino acid ester-substituted polyphosphazenes are unique biomaterials for tissue engineering. Considering the surface properties as topography and chemical composition having vital roles in regulating cellular response, in this study, a kind of micropatterned polyphosphazene films were prepared and subjected to osteoblasts culture. Briefly, poly(glycine ethyl ester-co-alanine ethyl ester)phosphazene (PGAP) was synthesized, and its solution in chloroform was cast under high (80%) or low (20%) environmental humidity. Honeycomb-patterned or flat PGAP films were resulted. By analyzing with scanning electron microscope, atomic force microscope, X-ray photoelectron spectroscope, and water contact angle measurement, the honeycomb-patterned PGAP films demonstrated higher surface roughness, phosphorous and nitrogen content, and hydrophilicity than the flat one. Although the initial cell attachment and proliferation on PGAP films were inferior to those on conventional poly(lactic-co-glycolic acid) films, P-containing PGAP was a sort of bone-binding bioactive polymer. With these alternations, honeycomb-patterned PGAP films had accordingly enhanced protein adsorption and apatite deposition in simulated body fluid and showed great advantages in promoting osteogenous differentiation. The results suggested a potential way to make polyphosphazenes as good choices for bone tissue regeneration by increasing their surface roughness and phosphorous content. (c) 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2013.
语种	英语
出版者	WILEY-BLACKWELL
WOS记录号	WOS:000312728000001
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/54325]
专题	中国科学院化学研究所
通讯作者	Cai, Qing
作者单位	1.Beijing Univ Chem Technol, State Key Lab Organ Inorgan Composites, Beijing 100029, Peoples R China 2.Chinese Acad Sci, Inst Chem, Ctr Mol Sci, Beijing 100190, Peoples R China 3.Peking Univ, Sch & Hosp Stomatol, Dept Geriatr Dent, Beijing 100081, Peoples R China
推荐引用方式 GB/T 7714	Duan, Shun,Yang, Xiaoping,Mao, Jifu,et al. Osteocompatibility evaluation of poly(glycine ethyl ester-co-alanine ethyl ester)phosphazene with honeycomb-patterned surface topography[J]. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A,2013,101(2):307-317.
APA	Duan, Shun.,Yang, Xiaoping.,Mao, Jifu.,Qi, Bing.,Cai, Qing.,...&Wang, Shenguo.(2013).Osteocompatibility evaluation of poly(glycine ethyl ester-co-alanine ethyl ester)phosphazene with honeycomb-patterned surface topography.JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A,101(2),307-317.
MLA	Duan, Shun,et al."Osteocompatibility evaluation of poly(glycine ethyl ester-co-alanine ethyl ester)phosphazene with honeycomb-patterned surface topography".JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A 101.2(2013):307-317.