No king without a crown - impact of the nanomaterial-protein corona on nanobiomedicine

doi:10.2217/nnm.14.184

CORC > 化学研究所 > 中国科学院化学研究所

	No king without a crown - impact of the nanomaterial-protein corona on nanobiomedicine
	Docter, Dominic 1; Strieth, Sebastian 1; Westmeier, Dana 1; Hayden, Oliver 2; Gao, Mingyuan 3; Knauer, Shirley K.4; Stauber, Roland H.1
刊名	NANOMEDICINE
	2015
卷号	10 期号:3 页码:503-519
关键词	Bioinformatics Blood System Colloidal Chemistry Label-free Quantification Mass Spectrometry Nanomaterials Nanomedicine Nanotoxicology Proteomics
ISSN号	1743-5889
DOI	10.2217/nnm.14.184
英文摘要	Besides the wide use of nanomaterials in technical products, their application spectrum in biotechnology and biomedicine is steadily increasing. Whereas the physico-chemical properties and behavior of nanomaterials can be engineered and characterized accurately under idealized conditions, this is no longer the case in complex physiological environments. In biological fluids, proteins rapidly bind to nanomaterials forming the protein corona, critically affecting the nanomaterials' biological identity. As the corona impacts in vitro and/or in vivo nanomaterial applications, we here review the concept of the protein corona and its analytical dissection. We comment on how corona signatures may be linked to effects at the nano-bio interface and conclude how such knowledge is offering novel opportunities for improved nanomedicine.
语种	英语
出版者	FUTURE MEDICINE LTD
WOS记录号	WOS:000350246600013
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/53371]
专题	中国科学院化学研究所
通讯作者	Docter, Dominic
作者单位	1.Univ Med Ctr Mainz, Dept Nanobiomed, ENT, D-55101 Mainz, Germany 2.Siemens AG, Corp Technol, D-91058 Erlangen, Germany 3.Chinese Acad Sci, Inst Chem, Beijing 100190, Peoples R China 4.Univ Duisburg Essen, CENIDE, Inst Mol Biol, D-45117 Essen, Germany
推荐引用方式 GB/T 7714	Docter, Dominic,Strieth, Sebastian,Westmeier, Dana,et al. No king without a crown - impact of the nanomaterial-protein corona on nanobiomedicine[J]. NANOMEDICINE,2015,10(3):503-519.
APA	Docter, Dominic.,Strieth, Sebastian.,Westmeier, Dana.,Hayden, Oliver.,Gao, Mingyuan.,...&Stauber, Roland H..(2015).No king without a crown - impact of the nanomaterial-protein corona on nanobiomedicine.NANOMEDICINE,10(3),503-519.
MLA	Docter, Dominic,et al."No king without a crown - impact of the nanomaterial-protein corona on nanobiomedicine".NANOMEDICINE 10.3(2015):503-519.