Effects of the surface charge on the stability of PEG-b-PCL micelles: simulation of the interactions between charged micelles and plasma components

doi:10.1039/c3py01281f

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	Effects of the surface charge on the stability of PEG-b-PCL micelles: simulation of the interactions between charged micelles and plasma components
	Wan, Yaoming 1; Gan, Zhihua 2; Li, Zhibo 1
刊名	POLYMER CHEMISTRY
	2014-03-07
卷号	5 期号:5 页码:1720-1727
ISSN号	1759-9954
DOI	10.1039/c3py01281f
英文摘要	Poly(ethylene oxide)-block-poly(epsilon-caprolactone) (PEG-b-PCL) copolymers with three kinds of terminal functional groups (amino, carboxyl and methoxyl) at the hydrophilic block end were synthesized via sequential ring-opening polymerization (ROP). Their structures were characterized by GPC and H-1 NMR. Micelles prepared from these copolymers showed different surface charge properties. The enzymatic degradation behaviour of these charged micelles in PBS (pH 7.0) was investigated using DLS, UV and TEM. BSA was used as a model protein to simulate the interactions between charged micelles and plasma components. It was found that micelles with different surface charges showed distinct degradation behaviour using lipase PS as the enzyme and different stability in the presence of BSA. Micelles with a neutral surface group showed a slow and partial degradation, while charged micelles showed a quick and complete degradation. We found that the nature of interactions between charged micelles and proteins was critical to the stability of polymeric micelles in vitro.
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000331987700023
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/52517]
专题	中国科学院化学研究所
通讯作者	Gan, Zhihua
作者单位	1.Chinese Acad Sci, Inst Chem, BNLMS, Beijing 100190, Peoples R China 2.Beijing Univ Chem Technol, Coll Life Sci & Technol, State Key Lab Organ Inorgan Composites, Beijing 100029, Peoples R China
推荐引用方式 GB/T 7714	Wan, Yaoming,Gan, Zhihua,Li, Zhibo. Effects of the surface charge on the stability of PEG-b-PCL micelles: simulation of the interactions between charged micelles and plasma components[J]. POLYMER CHEMISTRY,2014,5(5):1720-1727.
APA	Wan, Yaoming,Gan, Zhihua,&Li, Zhibo.(2014).Effects of the surface charge on the stability of PEG-b-PCL micelles: simulation of the interactions between charged micelles and plasma components.POLYMER CHEMISTRY,5(5),1720-1727.
MLA	Wan, Yaoming,et al."Effects of the surface charge on the stability of PEG-b-PCL micelles: simulation of the interactions between charged micelles and plasma components".POLYMER CHEMISTRY 5.5(2014):1720-1727.