Aggregation, Fusion, and Leakage of Liposomes Induced by Peptides

doi:10.1021/la501618f

CORC > 化学研究所 > 中国科学院化学研究所

	Aggregation, Fusion, and Leakage of Liposomes Induced by Peptides
	Xia, Yuqiong 3; Sun, Jianbo 1,2; Liang, Dehai 1,2
刊名	LANGMUIR
	2014-07-01
卷号	30 期号:25 页码:7334-7342
ISSN号	0743-7463
DOI	10.1021/la501618f
英文摘要	Biological membranes are heterogeneous systems. Their functions are closely related to the lipid lateral segregation in the presence of membrane proteins. In this work, we designed two peptides, amphiphilic cationic peptides K3L8K3 and nonamphiphilic peptides K-20, and studied their interactions with binary liposomes in different phases (L-omega L-beta', and L-alpha/L-beta'). As mimics of membrane proteins, both K3L8K3 and K-20 can cause the liposomes to aggregate, fuse, or leak. These processes were closely related to the phases of liposomes. For the liposomes in L-alpha phase, heavy aggregation, fusion, and leakage were observed in the presence of either K-20 or K3L8K3. For the liposomes in L-beta' phase, neither K3L8K3 nor K-20 can induce fusion or leakage. For the liposomes in L-alpha/L-beta' phase, K3L8K3 caused the liposomes to aggregate, fuse, and leak, while K-20 only led to aggregation. The kinetics of aggregation, fusion, and leakage in each phase were recorded, and they were related to the lipid demixing in the presence of the peptide. Our work not only gained insight into the effect of the lipid demixing on the interactions between peptide and membrane, but also helped in developing drug delivery vehicles with liposomes as the platform.
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000338488600011
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/52243]
专题	中国科学院化学研究所
通讯作者	Liang, Dehai
作者单位	1.Peking Univ, Beijing Natl Lab Mol Sci, Minist Educ, Coll Chem & Mol Engn, Beijing 100871, Peoples R China 2.Peking Univ, Key Lab Polymer Chem & Phys, Minist Educ, Coll Chem & Mol Engn, Beijing 100871, Peoples R China 3.Xidian Univ, Sch Life Sci & Technol, Xian 710126, Shaanxi, Peoples R China
推荐引用方式 GB/T 7714	Xia, Yuqiong,Sun, Jianbo,Liang, Dehai. Aggregation, Fusion, and Leakage of Liposomes Induced by Peptides[J]. LANGMUIR,2014,30(25):7334-7342.
APA	Xia, Yuqiong,Sun, Jianbo,&Liang, Dehai.(2014).Aggregation, Fusion, and Leakage of Liposomes Induced by Peptides.LANGMUIR,30(25),7334-7342.
MLA	Xia, Yuqiong,et al."Aggregation, Fusion, and Leakage of Liposomes Induced by Peptides".LANGMUIR 30.25(2014):7334-7342.