Synthesis of mesoporous silica nanoparticle-oxaliplatin conjugates for improved anticancer drug delivery

doi:10.1016/j.colsurfb.2014.02.014

CORC > 化学研究所 > 中国科学院化学研究所

	Synthesis of mesoporous silica nanoparticle-oxaliplatin conjugates for improved anticancer drug delivery
	He, Hongyan 1,2; Xiao, Haihua 3; Kuang, Huihui 1,2; Xie, Zhigang 1; Chen, Xuesi 1; Jing, Xiabin 1; Huang, Yubin 1
刊名	COLLOIDS AND SURFACES B-BIOINTERFACES
	2014-05-01
卷号	117 页码:75-81
关键词	Mesoporous Silica Nanoparticles (Msn) Oxaliplatin Conjugates Thiol-ene Click Drug Delivery
ISSN号	0927-7765
DOI	10.1016/j.colsurfb.2014.02.014
英文摘要	Mesoporous silica nanoparticles (MSN) with 1,2-bidentate carboxyl groups on the surface reacted with 1,2-diaminecyclohexano platinum(II) dinitrate (DACH-Pt-(NO3)2) which is an active anticancer species of clinic relevant oxaliplatin to form MSN-Pt. The modification of the parent particles was monitored by C-13, Si-29 solid-state NMR, X-ray measurements (XRD) and Fourier transform infrared spectroscopy (FT-IR). After loading with platinum drugs, MSN-Pt exhibited two strong Pt-4f signals as indicated by X-ray photoelectron spectroscopy (XPS). The platinum content in the conjugates was calculated to be 9.7% according to ICP-MS measurements. Confocal laser scanning microscopy (CLSM) displayed that MSN-Pt were uptaken fast by HepG-2 cells and concentrated within endosomes and lysosomes. In vitro MU assay of MSN-Pt demonstrated an improved cytotoxicity against HepG-2 cells than that of free oxaliplatin. This is due to the fact that MSN-Pt expressed higher platinum intracellular uptake and more DNA binding (Pt-DNA adducts) than free oxaliplatin. Hence this work highlighted that the platinum loaded MSN nanoparticles could be a promising future intelligent drug delivery system. (C) 2014 Elsevier B.V. All rights reserved.
语种	英语
出版者	ELSEVIER SCIENCE BV
WOS记录号	WOS:000336018700011
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/52143]
专题	中国科学院化学研究所
通讯作者	Huang, Yubin
作者单位	1.Changchun Inst Appl Chem, Chinese Acad Sci, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100039, Peoples R China 3.Univ Notre Dame, Dept Chem & Biomol Engn, Notre Dame, IN 46556 USA
推荐引用方式 GB/T 7714	He, Hongyan,Xiao, Haihua,Kuang, Huihui,et al. Synthesis of mesoporous silica nanoparticle-oxaliplatin conjugates for improved anticancer drug delivery[J]. COLLOIDS AND SURFACES B-BIOINTERFACES,2014,117:75-81.
APA	He, Hongyan.,Xiao, Haihua.,Kuang, Huihui.,Xie, Zhigang.,Chen, Xuesi.,...&Huang, Yubin.(2014).Synthesis of mesoporous silica nanoparticle-oxaliplatin conjugates for improved anticancer drug delivery.COLLOIDS AND SURFACES B-BIOINTERFACES,117,75-81.
MLA	He, Hongyan,et al."Synthesis of mesoporous silica nanoparticle-oxaliplatin conjugates for improved anticancer drug delivery".COLLOIDS AND SURFACES B-BIOINTERFACES 117(2014):75-81.