Supramolecular hydrogels assembled from nonionic poly(ethylene glycol)-b-polypeptide diblocks containing OEGylated poly-L-glutamate

doi:10.1039/c4py00016a

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	Supramolecular hydrogels assembled from nonionic poly(ethylene glycol)-b-polypeptide diblocks containing OEGylated poly-L-glutamate
	Zhang, Shusheng; Fu, Wenxin; Li, Zhibo
刊名	POLYMER CHEMISTRY
	2014
卷号	5 期号:10 页码:3346-3351
ISSN号	1759-9954
DOI	10.1039/c4py00016a
英文摘要	A poly(ethylene glycol)-b-poly(g-(2-methoxyethoxy)esteryl-L-glutamate) (PEG-b-poly-L-EG(2)Glu) diblock was prepared by the ring-opening polymerization (ROP) of L-EG(2)Glu N-carboxyanhydride (NCA) using PEG-NH2 as the macroinitiator. When the average degree of polymerization (DP) for poly-L-EG(2)Glu was below 40, the PEG-b-poly-L-EG(2)Glu diblock could spontaneously form hydrogels in water. For the different diblocks, a thermally-induced increase in mechanical strength was observed for the PEG-b-poly-L-EG(2)Glu diblock between 20-45 degrees C. Transmission electron microscopy (TEM) and atomic force microscopy (AFM) revealed that continuous networks of nanoribbons were formed in these hydrogel samples. Circular dichroism (CD) and Fourier transform infrared spectroscopy (FTIR) characterization suggested that the formation of sufficient beta-sheet content accounted for the nanoribbon assemblies and hydrogel networks. The minimal gelation concentration and gel mechanical properties were found to strongly depend on the composition of the PEG-b-poly-L-EG(2)Glu diblocks.
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000334833900009
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/51867]
专题	中国科学院化学研究所
通讯作者	Fu, Wenxin
作者单位	Chinese Acad Sci, Inst Chem, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Shusheng,Fu, Wenxin,Li, Zhibo. Supramolecular hydrogels assembled from nonionic poly(ethylene glycol)-b-polypeptide diblocks containing OEGylated poly-L-glutamate[J]. POLYMER CHEMISTRY,2014,5(10):3346-3351.
APA	Zhang, Shusheng,Fu, Wenxin,&Li, Zhibo.(2014).Supramolecular hydrogels assembled from nonionic poly(ethylene glycol)-b-polypeptide diblocks containing OEGylated poly-L-glutamate.POLYMER CHEMISTRY,5(10),3346-3351.
MLA	Zhang, Shusheng,et al."Supramolecular hydrogels assembled from nonionic poly(ethylene glycol)-b-polypeptide diblocks containing OEGylated poly-L-glutamate".POLYMER CHEMISTRY 5.10(2014):3346-3351.